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α-Linolenic acid-rich diet boosts docosahexaenoic acid levels and restores lipid balance in the brain parenchyma and vasculature of APOE4 mice.

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Title: α-Linolenic acid-rich diet boosts docosahexaenoic acid levels and restores lipid balance in the brain parenchyma and vasculature of APOE4 mice.
Authors: Leikin-Frenkel A; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Bert Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel., Ravid O; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel., Liberman M; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel., Atrakchi D; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel., Lamport V; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel., Rand D; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel., Harats D; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Bert Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel., Yassine HN; Department of Neurology, Keck School of Medicine, Los Angeles, California, USA; Center for Personalized Brain Health, University of Southern California, Los Angeles, California, USA., Sampath H; Department of Nutritional Sciences and Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey, USA., Michaelson DM; Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel., Schnaider-Beeri M; The Krieger Klein Alzheimer's Research Center, Brain Health Institute, Rutgers Health, New Jersey, USA., Liraz-Zaltsman S; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel; Department of Sports Therapy, Institutes for Health and Medical Professions, Ono Academic College, Kyrat-Ono, Israel., Cooper I; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel; School of Psychology, The Reichman University, Herzliya, Israel. Electronic address: Itzik.cooper@sheba.health.gov.il.
Source: The Journal of nutritional biochemistry [J Nutr Biochem] 2026 Aug; Vol. 154, pp. 110352. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE
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  Data: α-Linolenic acid-rich diet boosts docosahexaenoic acid levels and restores lipid balance in the brain parenchyma and vasculature of APOE4 mice.
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  Data: <searchLink fieldCode="AU" term="%22Leikin-Frenkel+A%22">Leikin-Frenkel A</searchLink>; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Bert Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Ravid+O%22">Ravid O</searchLink>; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Liberman+M%22">Liberman M</searchLink>; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Atrakchi+D%22">Atrakchi D</searchLink>; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Lamport+V%22">Lamport V</searchLink>; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Rand+D%22">Rand D</searchLink>; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Harats+D%22">Harats D</searchLink>; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Bert Strassburger Lipid Center, Sheba Medical Center, Tel-Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Yassine+HN%22">Yassine HN</searchLink>; Department of Neurology, Keck School of Medicine, Los Angeles, California, USA; Center for Personalized Brain Health, University of Southern California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Sampath+H%22">Sampath H</searchLink>; Department of Nutritional Sciences and Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Michaelson+DM%22">Michaelson DM</searchLink>; Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Schnaider-Beeri+M%22">Schnaider-Beeri M</searchLink>; The Krieger Klein Alzheimer's Research Center, Brain Health Institute, Rutgers Health, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Liraz-Zaltsman+S%22">Liraz-Zaltsman S</searchLink>; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel; Department of Sports Therapy, Institutes for Health and Medical Professions, Ono Academic College, Kyrat-Ono, Israel.<br /><searchLink fieldCode="AU" term="%22Cooper+I%22">Cooper I</searchLink>; Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel-Hashomer, Israel; School of Psychology, The Reichman University, Herzliya, Israel. Electronic address: Itzik.cooper@sheba.health.gov.il.
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  Data: <searchLink fieldCode="JN" term="%229010081%22">The Journal of nutritional biochemistry</searchLink> [J Nutr Biochem] 2026 Aug; Vol. 154, pp. 110352. <i>Date of Electronic Publication: </i>2026 Mar 24.
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