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Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes.

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Title: Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes.
Authors: Thomson RES; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Gumulya Y; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Bengochea AW; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Foley G; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Zaugg J; Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Aagaard A; Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ross CM; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Beckett J; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Bodén M; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia., Jurva U; Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hayes MA; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Andersson S; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Gillam EMJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia. e.gillam@uq.edu.au.
Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (9), pp. 2938-2964. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Thomson+RES%22">Thomson RES</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Gumulya+Y%22">Gumulya Y</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Bengochea+AW%22">Bengochea AW</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Foley+G%22">Foley G</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Zaugg+J%22">Zaugg J</searchLink>; Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Aagaard+A%22">Aagaard A</searchLink>; Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ross+CM%22">Ross CM</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Beckett+J%22">Beckett J</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Bodén+M%22">Bodén M</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Jurva+U%22">Jurva U</searchLink>; Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Hayes+MA%22">Hayes MA</searchLink>; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Andersson+S%22">Andersson S</searchLink>; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Gillam+EMJ%22">Gillam EMJ</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia. e.gillam@uq.edu.au.
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