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Beyond the mouse: 3R-guided alternative animal models transforming cancer research.

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Title: Beyond the mouse: 3R-guided alternative animal models transforming cancer research.
Authors: Faehling T; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Paediatric Oncology, Haematology, Oncology and Immunology, Heidelberg University Hospital, Heidelberg, Germany., Reiff T; Institute of Genetics Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Schumacher B; Institute for Genome Stability in Aging and Disease, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University and University Hospital Cologne, Cologne, Germany., Arndt R; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Medicine, Heidelberg University, Heidelberg, Germany., Amatruda JF; Cancer and Blood Disease Institute, Division of Hematology-Oncology, Children's Hospital, Los Angeles, CA, USA.; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Grünewald TGP; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Cidre-Aranaz F; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. florencia.cidrearanaz@dkfz.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. florencia.cidrearanaz@dkfz.de.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. florencia.cidrearanaz@dkfz.de.
Source: Molecular cancer [Mol Cancer] 2026 Mar 26; Vol. 25 (1). Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Beyond the mouse: 3R-guided alternative animal models transforming cancer research.
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  Data: <searchLink fieldCode="AU" term="%22Faehling+T%22">Faehling T</searchLink>; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Paediatric Oncology, Haematology, Oncology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Reiff+T%22">Reiff T</searchLink>; Institute of Genetics Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Schumacher+B%22">Schumacher B</searchLink>; Institute for Genome Stability in Aging and Disease, University and University Hospital of Cologne, Cologne, Germany.; Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University and University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Arndt+R%22">Arndt R</searchLink>; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Faculty of Medicine, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Amatruda+JF%22">Amatruda JF</searchLink>; Cancer and Blood Disease Institute, Division of Hematology-Oncology, Children's Hospital, Los Angeles, CA, USA.; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Grünewald+TGP%22">Grünewald TGP</searchLink>; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cidre-Aranaz+F%22">Cidre-Aranaz F</searchLink>; Hopp Children`s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. florencia.cidrearanaz@dkfz.de.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. florencia.cidrearanaz@dkfz.de.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. florencia.cidrearanaz@dkfz.de.
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  Data: <searchLink fieldCode="JN" term="%22101147698%22">Molecular cancer</searchLink> [Mol Cancer] 2026 Mar 26; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 Mar 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147698 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214764598%22">14764598 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12943-026-02601-0
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              Text: 2026 Mar 26
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