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N-aryl-N-acyl diamine derivatives as novel selective serotonin/norepinephrine transporter inhibitors for the treatment of premature ejaculation.

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Title: N-aryl-N-acyl diamine derivatives as novel selective serotonin/norepinephrine transporter inhibitors for the treatment of premature ejaculation.
Authors: Cui W; School of Pharmacy, Nantong University, 9 Seyuan Road, Nantong, 226019, China; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Nie K; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Jin F; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Li P; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Hou Q; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Hu T; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., Tian G; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China., He Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Fan B; School of Pharmacy, Nantong University, 9 Seyuan Road, Nantong, 226019, China. Electronic address: fanboyi@ntu.edu.cn., Wang G; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China. Electronic address: guan.wang@vigonvita.cn., Shen J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jun 05; Vol. 310, pp. 118771. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: N-aryl-N-acyl diamine derivatives as novel selective serotonin/norepinephrine transporter inhibitors for the treatment of premature ejaculation.
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  Data: <searchLink fieldCode="AU" term="%22Cui+W%22">Cui W</searchLink>; School of Pharmacy, Nantong University, 9 Seyuan Road, Nantong, 226019, China; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Nie+K%22">Nie K</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Hou+Q%22">Hou Q</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Hu+T%22">Hu T</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Tian+G%22">Tian G</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Fan+B%22">Fan B</searchLink>; School of Pharmacy, Nantong University, 9 Seyuan Road, Nantong, 226019, China. Electronic address: fanboyi@ntu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; Vigonvita Shanghai Co., Ltd., Shanghai, 201210, China. Electronic address: guan.wang@vigonvita.cn.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Jun 05; Vol. 310, pp. 118771. <i>Date of Electronic Publication: </i>2026 Mar 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118771
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        Text: English
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        StartPage: 118771
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            – D: 05
              M: 06
              Text: 2026 Jun 05
              Type: published
              Y: 2026
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