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Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling.

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Title: Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling.
Authors: Liu J; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Gonzalez-Hunt CP; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Richbourg T; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Barraza I; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Chen C; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Montes C; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Ma L; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Cao R; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Hanumaihgari V; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA., Gassman NR; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA., Fouquerel E; UPMC Hillman Cancer Center, Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15232, USA., Sanders LH; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 01. Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and PARP1 hyperactive signaling.
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  Data: <searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Hunt+CP%22">Gonzalez-Hunt CP</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Richbourg+T%22">Richbourg T</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Barraza+I%22">Barraza I</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Montes+C%22">Montes C</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cao+R%22">Cao R</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Hanumaihgari+V%22">Hanumaihgari V</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Gassman+NR%22">Gassman NR</searchLink>; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA.<br /><searchLink fieldCode="AU" term="%22Fouquerel+E%22">Fouquerel E</searchLink>; UPMC Hillman Cancer Center, Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15232, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+LH%22">Sanders LH</searchLink>; Departments of Neurology and Pathology, Duke University School of Medicine, Durham, North Carolina, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, North Carolina, 27710, USA.
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              Text: 2026 Mar 01
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