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Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors.

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Title: Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors.
Authors: Liu Y; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Zhang Z; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Tao Y; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA., Rahgav L; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Gray-Gaillard S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Hussaini Y; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Pan M; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Shamber J; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Kwak J; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Park SL; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Cramer J; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Stoltz R; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Patria J; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Swanger J; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Liu K; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Sannigrahi MK; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Houghton AM; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Rodriguez CP; Department of Medicine, University of Washington, Seattle, WA., Carey RM; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Brody R; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Rajasekaran K; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Weinstein G; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Linette GP; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA., Carreno BM; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA., Painter MM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Clurman B; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Medicine, University of Washington, Seattle, WA., Basu D; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Diab A; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.; Penn Center for Genomic Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 17. Date of Electronic Publication: 2026 Mar 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV<superscript>+</superscript> tumors.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Rahgav+L%22">Rahgav L</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Gray-Gaillard+S%22">Gray-Gaillard S</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hussaini+Y%22">Hussaini Y</searchLink>; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Pan+M%22">Pan M</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Shamber+J%22">Shamber J</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Kwak+J%22">Kwak J</searchLink>; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Park+SL%22">Park SL</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Cramer+J%22">Cramer J</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Stoltz+R%22">Stoltz R</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Patria+J%22">Patria J</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Swanger+J%22">Swanger J</searchLink>; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Sannigrahi+MK%22">Sannigrahi MK</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Houghton+AM%22">Houghton AM</searchLink>; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+CP%22">Rodriguez CP</searchLink>; Department of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Carey+RM%22">Carey RM</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Brody+R%22">Brody R</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Rajasekaran+K%22">Rajasekaran K</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Weinstein+G%22">Weinstein G</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Linette+GP%22">Linette GP</searchLink>; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Carreno+BM%22">Carreno BM</searchLink>; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Painter+MM%22">Painter MM</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Wherry+EJ%22">Wherry EJ</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Clurman+B%22">Clurman B</searchLink>; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Medicine, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Basu+D%22">Basu D</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Diab+A%22">Diab A</searchLink>; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.; Penn Center for Genomic Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
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