Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors.
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| Title: | Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors. |
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| Authors: | Liu Y; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Zhang Z; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Tao Y; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA., Rahgav L; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Gray-Gaillard S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Hussaini Y; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Pan M; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Shamber J; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Kwak J; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Park SL; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Cramer J; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Stoltz R; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Patria J; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Swanger J; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Liu K; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Sannigrahi MK; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Houghton AM; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA., Rodriguez CP; Department of Medicine, University of Washington, Seattle, WA., Carey RM; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Brody R; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Rajasekaran K; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Weinstein G; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Linette GP; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA., Carreno BM; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA., Painter MM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA., Clurman B; Translational Therapeutics and Human Biology Divisions, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Medicine, University of Washington, Seattle, WA., Basu D; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Diab A; Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, PA.; Penn Center for Genomic Integrity, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 17. Date of Electronic Publication: 2026 Mar 17. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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