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IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing Antibody.

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Title: IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing Antibody.
Authors: Kumar S; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; ICGEB-Emory Vaccine Program, International Centre for Genetic Engineering and Biotechnology, New Delhi, India., Scott CAP; School of Chemistry and Molecular Biosciences, The University of Queensland St Lucia, Brisbane, Australia.; Australian Infectious Diseases Research Centre, Brisbane, Australia., Xu L; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA., Moore K; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Velden JV; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Shih S; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA., West RH; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA., Gupta SL; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA., Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland St Lucia, Brisbane, Australia.; Australian Infectious Diseases Research Centre, Brisbane, Australia., Suthar MS; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA., Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland St Lucia, Brisbane, Australia.; Australian Infectious Diseases Research Centre, Brisbane, Australia., Wrammert J; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 29. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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  Data: IgG3 Hinge Architecture Expands Dengue Virus Breadth of A Quaternary Epitope Dependent Zika Virus Cross-Neutralizing Antibody.
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  Data: <searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; ICGEB-Emory Vaccine Program, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Scott+CAP%22">Scott CAP</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland St Lucia, Brisbane, Australia.; Australian Infectious Diseases Research Centre, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+K%22">Moore K</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Velden+JV%22">Velden JV</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Shih+S%22">Shih S</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22West+RH%22">West RH</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+SL%22">Gupta SL</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Modhiran+N%22">Modhiran N</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland St Lucia, Brisbane, Australia.; Australian Infectious Diseases Research Centre, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Suthar+MS%22">Suthar MS</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.; Emory National Primate Research Center, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Watterson+D%22">Watterson D</searchLink>; School of Chemistry and Molecular Biosciences, The University of Queensland St Lucia, Brisbane, Australia.; Australian Infectious Diseases Research Centre, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Wrammert+J%22">Wrammert J</searchLink>; Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Centers for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Emory University, Department of Pediatrics, Department of Medicine, Atlanta, GA, USA.
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