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Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation.

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Title: Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation.
Authors: Pollin G; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Mathison AJ; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Leverence EN; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA., De Assuncao TM; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), Institut National de la Santé et de la Recherche Médicale (INSERM) U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 09, France., Hong JC; Department of Solid Organ Transplantation and Hepatobiliary Surgery, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH 43608, USA., Zimmermann MT; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Data Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Urrutia R; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Centre de Recherche en Cancérologie de Marseille (CRCM), Institut National de la Santé et de la Recherche Médicale (INSERM) U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 09, France.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Lomberk G; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Phoenix, AZ 85054, USA.
Source: Epigenomes [Epigenomes] 2026 Mar 10; Vol. 10 (1). Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101736595 Publication Model: Electronic Cited Medium: Internet ISSN: 2075-4655 (Electronic) Linking ISSN: 20754655 NLM ISO Abbreviation: Epigenomes Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Pollin+G%22">Pollin G</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Mathison+AJ%22">Mathison AJ</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Leverence+EN%22">Leverence EN</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22De+Assuncao+TM%22">De Assuncao TM</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Iovanna+J%22">Iovanna J</searchLink>; Centre de Recherche en Cancérologie de Marseille (CRCM), Institut National de la Santé et de la Recherche Médicale (INSERM) U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 09, France.<br /><searchLink fieldCode="AU" term="%22Hong+JC%22">Hong JC</searchLink>; Department of Solid Organ Transplantation and Hepatobiliary Surgery, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, OH 43608, USA.<br /><searchLink fieldCode="AU" term="%22Zimmermann+MT%22">Zimmermann MT</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Data Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Urrutia+R%22">Urrutia R</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Centre de Recherche en Cancérologie de Marseille (CRCM), Institut National de la Santé et de la Recherche Médicale (INSERM) U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 09, France.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.<br /><searchLink fieldCode="AU" term="%22Lomberk+G%22">Lomberk G</searchLink>; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Phoenix, AZ 85054, USA.
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              Text: 2026 Mar 10
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