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Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma.

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Title: Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma.
Authors: de Sousa AC; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Weber AF; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Klain V; One Health Research Group, Biotechnology Center, Graduate Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Scholl JN; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Ramos JMO; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Nascimento NBD; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Giehl ML; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Martins RK; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Heres JV; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Dias CK; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Marschner R; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Figueiró F; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil., Guma FCR; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
Source: Metabolites [Metabolites] 2026 Feb 25; Vol. 16 (3). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
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  Data: Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22de+Sousa+AC%22">de Sousa AC</searchLink>; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Weber+AF%22">Weber AF</searchLink>; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Klain+V%22">Klain V</searchLink>; One Health Research Group, Biotechnology Center, Graduate Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Scholl+JN%22">Scholl JN</searchLink>; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Ramos+JMO%22">Ramos JMO</searchLink>; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Nascimento+NBD%22">Nascimento NBD</searchLink>; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Giehl+ML%22">Giehl ML</searchLink>; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+RK%22">Martins RK</searchLink>; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Heres+JV%22">Heres JV</searchLink>; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+CK%22">Dias CK</searchLink>; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Marschner+R%22">Marschner R</searchLink>; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Figueiró+F%22">Figueiró F</searchLink>; Laboratory of Cancer Immunobiochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Guma+FCR%22">Guma FCR</searchLink>; Laboratory of Differentiation, Proliferation, and Cell Viability, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.; Graduate Program in Biological Sciences, Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90610-264, RS, Brazil.
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