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Temozolomide in aggressive and metastatic pituitary tumors: a Brazilian multicenter real-world cohort study.

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Title: Temozolomide in aggressive and metastatic pituitary tumors: a Brazilian multicenter real-world cohort study.
Authors: de Magalhães IPA; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., de Macedo CRPB; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Naves LA; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil., Czepielewski MA; Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Rosa IN; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil., de Santana LB; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil., de Almeida TS; Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Padula M; Division of Radiology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Elias PCL; Department of Internal Medicine, Division of Endocrinology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., de Castro M; Department of Internal Medicine, Division of Endocrinology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Kasuki L; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Gadelha MR; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Rech CGSL; Neuroendocrinology Center, Santa Casa of Porto Alegre, Porto Alegre, Brazil., Garmes HM; Service of Endocrinology, Department of Clinical Medicine, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Brazil., Boguszewski CL; Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of Paraná, Curitiba, Paraná, Brazil., Jallad RS; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Nakaguma M; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Fragoso MCBV; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Cancer Institute of the State of São Paulo (ICESP), Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Machado MC; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Glezer A; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., da Cunha Neto MBC; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Feher O; Cancer Institute of the State of São Paulo (ICESP), Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Batista RL; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. rafael.loch@hc.fm.usp.br.; Cancer Institute of the State of São Paulo (ICESP), Faculty of Medicine, University of São Paulo, São Paulo, Brazil. rafael.loch@hc.fm.usp.br.; Endocrine Genetics Laboratory, LIM-42, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César, São Paulo, SP, 05403-000, Brazil. rafael.loch@hc.fm.usp.br.
Source: Pituitary [Pituitary] 2026 Mar 27; Vol. 29 (2). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: United States NLM ID: 9814578 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7403 (Electronic) Linking ISSN: 1386341X NLM ISO Abbreviation: Pituitary Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Temozolomide in aggressive and metastatic pituitary tumors: a Brazilian multicenter real-world cohort study.
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  Data: <searchLink fieldCode="AU" term="%22de+Magalhães+IPA%22">de Magalhães IPA</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Macedo+CRPB%22">de Macedo CRPB</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Naves+LA%22">Naves LA</searchLink>; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22Czepielewski+MA%22">Czepielewski MA</searchLink>; Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Rosa+IN%22">Rosa IN</searchLink>; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Santana+LB%22">de Santana LB</searchLink>; Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Almeida+TS%22">de Almeida TS</searchLink>; Endocrinology Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Padula+M%22">Padula M</searchLink>; Division of Radiology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Elias+PCL%22">Elias PCL</searchLink>; Department of Internal Medicine, Division of Endocrinology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Castro+M%22">de Castro M</searchLink>; Department of Internal Medicine, Division of Endocrinology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Kasuki+L%22">Kasuki L</searchLink>; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Gadelha+MR%22">Gadelha MR</searchLink>; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Rech+CGSL%22">Rech CGSL</searchLink>; Neuroendocrinology Center, Santa Casa of Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Garmes+HM%22">Garmes HM</searchLink>; Service of Endocrinology, Department of Clinical Medicine, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Boguszewski+CL%22">Boguszewski CL</searchLink>; Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of Paraná, Curitiba, Paraná, Brazil.<br /><searchLink fieldCode="AU" term="%22Jallad+RS%22">Jallad RS</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Nakaguma+M%22">Nakaguma M</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Fragoso+MCBV%22">Fragoso MCBV</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Cancer Institute of the State of São Paulo (ICESP), Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+MC%22">Machado MC</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Glezer+A%22">Glezer A</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Cunha+Neto+MBC%22">da Cunha Neto MBC</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Feher+O%22">Feher O</searchLink>; Cancer Institute of the State of São Paulo (ICESP), Faculty of Medicine, University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Batista+RL%22">Batista RL</searchLink>; Neuroendocrinology Unit, Division of Metabolism and Endocrinology, Department of Internal Medicine, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. rafael.loch@hc.fm.usp.br.; Cancer Institute of the State of São Paulo (ICESP), Faculty of Medicine, University of São Paulo, São Paulo, Brazil. rafael.loch@hc.fm.usp.br.; Endocrine Genetics Laboratory, LIM-42, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César, São Paulo, SP, 05403-000, Brazil. rafael.loch@hc.fm.usp.br.
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