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IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response.

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Title: IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response.
Authors: Bendig S; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Hartmann AM; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Wessels W; Children's Cancer Institute, Sydney, Australia., Beder T; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Kim R; Hematology Laboratory, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France., Passet M; Hematology Laboratory, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France., Gao Q; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States., Wolgast N; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Horns JM; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Alves Santos L; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Iben K; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Steffen FD; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland., Cantoni L; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland., Kehden B; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Chitadze G; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Künstner A; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany., Busch H; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany., Bornhauser B; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland., Bourquin JP; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland., Leguay TT; Hematology Department, CHU de Bordeaux, Hôpital du Haut-Levêque, Pessac, France., Boissel N; Hematology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, Paris, France., Gökbuget N; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States., Clappier E; Hematology Laboratory, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France., Baldus CD; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Brüggemann M; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany., Bastian L; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.
Source: Blood [Blood] 2026 Mar 27. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IGH::FENDRR and specific KRAS mutations define a novel B-ALL molecular subtype with poor chemotherapy response.
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  Data: <searchLink fieldCode="AU" term="%22Bendig+S%22">Bendig S</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Hartmann+AM%22">Hartmann AM</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Wessels+W%22">Wessels W</searchLink>; Children's Cancer Institute, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Beder+T%22">Beder T</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Kim+R%22">Kim R</searchLink>; Hematology Laboratory, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Passet+M%22">Passet M</searchLink>; Hematology Laboratory, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.<br /><searchLink fieldCode="AU" term="%22Wolgast+N%22">Wolgast N</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Horns+JM%22">Horns JM</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Alves+Santos+L%22">Alves Santos L</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Iben+K%22">Iben K</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Steffen+FD%22">Steffen FD</searchLink>; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cantoni+L%22">Cantoni L</searchLink>; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kehden+B%22">Kehden B</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Chitadze+G%22">Chitadze G</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Künstner+A%22">Künstner A</searchLink>; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Busch+H%22">Busch H</searchLink>; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bourquin+JP%22">Bourquin JP</searchLink>; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Leguay+TT%22">Leguay TT</searchLink>; Hematology Department, CHU de Bordeaux, Hôpital du Haut-Levêque, Pessac, France.<br /><searchLink fieldCode="AU" term="%22Boissel+N%22">Boissel N</searchLink>; Hematology Department, Hôpital Saint-Louis, AP-HP, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gökbuget+N%22">Gökbuget N</searchLink>; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Iacobucci+I%22">Iacobucci I</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.<br /><searchLink fieldCode="AU" term="%22Mullighan+CG%22">Mullighan CG</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, United States.<br /><searchLink fieldCode="AU" term="%22Clappier+E%22">Clappier E</searchLink>; Hematology Laboratory, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Baldus+CD%22">Baldus CD</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Brüggemann+M%22">Brüggemann M</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Bastian+L%22">Bastian L</searchLink>; Medical Department II, Hematology/Oncology, University Hospital Schleswig-Holstein, Kiel, Germany.
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