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Primary human intestinal organoids model enteric infection of monkeypox virus and enable scalable drug discovery.

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Title: Primary human intestinal organoids model enteric infection of monkeypox virus and enable scalable drug discovery.
Authors: Li P; Precision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Wang X; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Zhou J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Yao Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China., Wang Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Xu G; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Schraauwen R; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., da Silva AMG; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., de Henau C; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, Netherlands., Incitti R; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia., Offermans DM; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., de Vries AC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Kainov DE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway., Alam I; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia., Raymond K; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, Netherlands.; University of Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, Grenoble, France., Duarte-Neto AN; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Bijvelds MJC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
Source: Science advances [Sci Adv] 2026 Mar 27; Vol. 12 (13), pp. eaea8280. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Primary human intestinal organoids model enteric infection of monkeypox virus and enable scalable drug discovery.
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  Data: <searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Precision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Yao+Y%22">Yao Y</searchLink>; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schraauwen+R%22">Schraauwen R</searchLink>; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22da+Silva+AMG%22">da Silva AMG</searchLink>; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Henau+C%22">de Henau C</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Incitti+R%22">Incitti R</searchLink>; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Offermans+DM%22">Offermans DM</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vries+AC%22">de Vries AC</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kainov+DE%22">Kainov DE</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Alam+I%22">Alam I</searchLink>; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Raymond+K%22">Raymond K</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, Netherlands.; University of Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Duarte-Neto+AN%22">Duarte-Neto AN</searchLink>; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Bijvelds+MJC%22">Bijvelds MJC</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Mar 27; Vol. 12 (13), pp. eaea8280. <i>Date of Electronic Publication: </i>2026 Mar 27.
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