Primary human intestinal organoids model enteric infection of monkeypox virus and enable scalable drug discovery.
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| Title: | Primary human intestinal organoids model enteric infection of monkeypox virus and enable scalable drug discovery. |
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| Authors: | Li P; Precision Medicine Translational Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Wang X; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Zhou J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Yao Y; State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China., Wang Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Xu G; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Schraauwen R; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., da Silva AMG; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., de Henau C; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, Netherlands., Incitti R; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia., Offermans DM; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., de Vries AC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Kainov DE; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway., Alam I; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia., Raymond K; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, Netherlands.; The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center, Leiden, Netherlands.; University of Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, Grenoble, France., Duarte-Neto AN; Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Bijvelds MJC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, Netherlands. |
| Source: | Science advances [Sci Adv] 2026 Mar 27; Vol. 12 (13), pp. eaea8280. Date of Electronic Publication: 2026 Mar 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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