Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development.
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| Title: | Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development. |
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| Authors: | Sane RS; Clinical Pharmacology, Genentech, Inc., South San Francisco, California. Electronic address: sane.rucha@gene.com., Mitra P; Department of Clinical Pharmacology & Nonclinical Safety Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut., Lai Y; Drug Metabolism, Gilead Sciences, Inc, Foster City, California., Li CY; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, California., Shen H; Department of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb Research and Development, Princeton, New Jersey., Tohyama K; Takeda Pharmaceutical Company Limited, Fujisawa, Japan., Costales C; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Research and Development, Pfizer Inc., Groton, Connecticut., Salphati L; Departments of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, California., Mahar KM; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania., Bow DAJ; Quantitative, Translational and ADME Sciences, AbbVie Inc, North Chicago, Illinois., Vergis JM; IQ Secretariat, Faegre Drinker Biddle & Reath LLP, Washington, District of Columbia., Brumm J; Nonclinical Biostatistics, Genentech, Inc, South San Francisco, California., Taskar K; DMPK Modeling, IVIVT, Research, GSK, Stevenage, United Kingdom., Chanteux H; Quantitative Clinical Pharmacology, Early Clinical Development & Translational Sciences, UCB Biopharma SRL, Braine-L'Alleud, Belgium., Fang Z; NCE Drug Metabolism and Pharmacokinetics, the Healthcare Business of Merck KGaA, Darmstadt, Germany., Liang X; Drug Metabolism, Gilead Sciences, Inc, Foster City, California., Park SH; Preclinical Sciences and Translational Safety, Johnson & Johnson, Spring House, Pennsylvania., Hanna I; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, East Hanover, New Jersey., Thakkar N; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania., Chu X; Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & Co, Inc, Rahway, New Jersey., Hop CECA; Departments of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, California., Rollison HE; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Taub ME; Department of Clinical Pharmacology & Nonclinical Safety Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut., Kimoto E; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Research and Development, Pfizer Inc., Groton, Connecticut., Fenner KS; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Xu C; Pharmacokinetics, Dynamics, and Metabolism, Translational Medicine and Early Development, Sanofi US, Bridgewater, New Jersey., Hillgren KM; Investigative Drug Disposition, Lilly Research Laboratories, Eli Lilly Inc, Indianapolis, Indiana. |
| Source: | Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 Apr; Vol. 54 (4), pp. 100255. Date of Electronic Publication: 2026 Feb 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41894930 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sane+RS%22">Sane RS</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California. Electronic address: sane.rucha@gene.com.<br /><searchLink fieldCode="AU" term="%22Mitra+P%22">Mitra P</searchLink>; Department of Clinical Pharmacology & Nonclinical Safety Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Drug Metabolism, Gilead Sciences, Inc, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Li+CY%22">Li CY</searchLink>; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb Research and Development, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Tohyama+K%22">Tohyama K</searchLink>; Takeda Pharmaceutical Company Limited, Fujisawa, Japan.<br /><searchLink fieldCode="AU" term="%22Costales+C%22">Costales C</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Research and Development, Pfizer Inc., Groton, Connecticut.<br /><searchLink fieldCode="AU" term="%22Salphati+L%22">Salphati L</searchLink>; Departments of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Mahar+KM%22">Mahar KM</searchLink>; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Bow+DAJ%22">Bow DAJ</searchLink>; Quantitative, Translational and ADME Sciences, AbbVie Inc, North Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Vergis+JM%22">Vergis JM</searchLink>; IQ Secretariat, Faegre Drinker Biddle & Reath LLP, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Brumm+J%22">Brumm J</searchLink>; Nonclinical Biostatistics, Genentech, Inc, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Taskar+K%22">Taskar K</searchLink>; DMPK Modeling, IVIVT, Research, GSK, Stevenage, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chanteux+H%22">Chanteux H</searchLink>; Quantitative Clinical Pharmacology, Early Clinical Development & Translational Sciences, UCB Biopharma SRL, Braine-L'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Fang+Z%22">Fang Z</searchLink>; NCE Drug Metabolism and Pharmacokinetics, the Healthcare Business of Merck KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Drug Metabolism, Gilead Sciences, Inc, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; Preclinical Sciences and Translational Safety, Johnson & Johnson, Spring House, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Hanna+I%22">Hanna I</searchLink>; Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, East Hanover, New Jersey.<br /><searchLink fieldCode="AU" term="%22Thakkar+N%22">Thakkar N</searchLink>; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline Research and Development, Collegeville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Chu+X%22">Chu X</searchLink>; Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics, Merck & Co, Inc, Rahway, New Jersey.<br /><searchLink fieldCode="AU" term="%22Hop+CECA%22">Hop CECA</searchLink>; Departments of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Rollison+HE%22">Rollison HE</searchLink>; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Taub+ME%22">Taub ME</searchLink>; Department of Clinical Pharmacology & Nonclinical Safety Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut.<br /><searchLink fieldCode="AU" term="%22Kimoto+E%22">Kimoto E</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Research and Development, Pfizer Inc., Groton, Connecticut.<br /><searchLink fieldCode="AU" term="%22Fenner+KS%22">Fenner KS</searchLink>; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Translational Medicine and Early Development, Sanofi US, Bridgewater, New Jersey.<br /><searchLink fieldCode="AU" term="%22Hillgren+KM%22">Hillgren KM</searchLink>; Investigative Drug Disposition, Lilly Research Laboratories, Eli Lilly Inc, Indianapolis, Indiana. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229421550%22">Drug metabolism and disposition: the biological fate of chemicals</searchLink> [Drug Metab Dispos] 2026 Apr; Vol. 54 (4), pp. 100255. <i>Date of Electronic Publication: </i>2026 Feb 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Pharmacology+and+Experimental+Therapeutics%2C+etc%2E]%22">American Society for Pharmacology and Experimental Therapeutics, etc.] </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9421550 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-009X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200909556%22">00909556 </searchLink><i>NLM ISO Abbreviation: </i>Drug Metab Dispos <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41894930 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.dmd.2026.100255 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 100255 Titles: – TitleFull: Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sane RS – PersonEntity: Name: NameFull: Mitra P – PersonEntity: Name: NameFull: Lai Y – PersonEntity: Name: NameFull: Li CY – PersonEntity: Name: NameFull: Shen H – PersonEntity: Name: NameFull: Tohyama K – PersonEntity: Name: NameFull: Costales C – PersonEntity: Name: NameFull: Salphati L – PersonEntity: Name: NameFull: Mahar KM – PersonEntity: Name: NameFull: Bow DAJ – PersonEntity: Name: NameFull: Vergis JM – PersonEntity: Name: NameFull: Brumm J – PersonEntity: Name: NameFull: Taskar K – PersonEntity: Name: NameFull: Chanteux H – PersonEntity: Name: NameFull: Fang Z – PersonEntity: Name: NameFull: Liang X – PersonEntity: Name: NameFull: Park SH – PersonEntity: Name: NameFull: Hanna I – PersonEntity: Name: NameFull: Thakkar N – PersonEntity: Name: NameFull: Chu X – PersonEntity: Name: NameFull: Hop CECA – PersonEntity: Name: NameFull: Rollison HE – PersonEntity: Name: NameFull: Taub ME – PersonEntity: Name: NameFull: Kimoto E – PersonEntity: Name: NameFull: Fenner KS – PersonEntity: Name: NameFull: Xu C – PersonEntity: Name: NameFull: Hillgren KM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1521-009X Numbering: – Type: volume Value: 54 – Type: issue Value: 4 Titles: – TitleFull: Drug metabolism and disposition: the biological fate of chemicals Type: main |
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