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3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease.

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Title: 3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease.
Authors: Vila Cuenca M; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands., Tsikari T; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands., Cerfontaine MN; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., Gallant JL; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands., van den Hil FE; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands., Bouma MJ; Leiden University Medical Center hiPSC Center, Leiden, the Netherlands., Dijkstra KL; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Gravesteijn G; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., de Vries AAF; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Mummery CL; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands., Rutten JW; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: j.w.rutten@lumc.nl., Lesnik Oberstein SAJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: s.a.m.j.lesnik@lumc.nl., Orlova VV; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: v.orlova@lumc.nl.
Source: Stem cell reports [Stem Cell Reports] 2026 Apr 14; Vol. 21 (4), pp. 102863. Date of Electronic Publication: 2026 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
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  Data: 3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease.
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  Data: <searchLink fieldCode="AU" term="%22Vila+Cuenca+M%22">Vila Cuenca M</searchLink>; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tsikari+T%22">Tsikari T</searchLink>; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cerfontaine+MN%22">Cerfontaine MN</searchLink>; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gallant+JL%22">Gallant JL</searchLink>; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Hil+FE%22">van den Hil FE</searchLink>; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bouma+MJ%22">Bouma MJ</searchLink>; Leiden University Medical Center hiPSC Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dijkstra+KL%22">Dijkstra KL</searchLink>; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gravesteijn+G%22">Gravesteijn G</searchLink>; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vries+AAF%22">de Vries AAF</searchLink>; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mummery+CL%22">Mummery CL</searchLink>; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rutten+JW%22">Rutten JW</searchLink>; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: j.w.rutten@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Lesnik+Oberstein+SAJ%22">Lesnik Oberstein SAJ</searchLink>; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: s.a.m.j.lesnik@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Orlova+VV%22">Orlova VV</searchLink>; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: v.orlova@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101611300%22">Stem cell reports</searchLink> [Stem Cell Reports] 2026 Apr 14; Vol. 21 (4), pp. 102863. <i>Date of Electronic Publication: </i>2026 Mar 26.
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