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Intermediate dose heparin thromboprophylaxis among critically ill patients with COVID-19: a randomized clinical trial.

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Title: Intermediate dose heparin thromboprophylaxis among critically ill patients with COVID-19: a randomized clinical trial.
Authors: Bradbury CA; Faculty of Health Sciences, University of Bristol, Bristol, UK. Electronic address: c.bradbury@bristol.ac.uk., McVerry BJ; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lawler PR; Peter Munk Cardiac Centre at University Health Network, Toronto, Canada; University of Toronto, Toronto, Canada., Angus DC; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Annane D; Université Versailles Saint-Quentin-en-Yvelines - Université Paris Saclay, Montigny-le-Bretonneux, France., Arabi YM; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Ara., Aryal D; Nepal Mediciti Hospital, Lalitpur, Nepal., Au C; Intensive Care National Audit & Research Centre (ICNARC), London, UK., Beane A; Oxford University, Oxford, UK., Berry SM; Berry Consultants, Austin, Texas, USA., Berry LR; Berry Consultants, Austin, Texas, USA., Best-Lane J; Imperial College London, London, UK., Bihari S; Flinders University, Bedford Park, Australia., Bonten M; University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Brunkhorst F; Jena University Hospital, Jena, Germany., Burrell A; Monash University, Melbourne, Australia., Buxton M; Global Coalition for Adaptive Research, Los Angeles, California, USA., Carrier M; Ottawa Hospital Research Institute, Ottawa, Canada., Cecconi M; Humanitas Research Hospital, Rozzano (Milan), Italy., Cheng AC; Monash University, Melbourne, Australia., Cove M; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Derde LPG; University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Detry MA; Berry Consultants, Austin, Texas, USA., Estcourt LJ; National Health Service Blood and Transplant, Oxford, UK., Fergusson DA; Ottawa Hospital Research Institute, Ottawa, Canada., Fitzgerald M; Berry Consultants, Austin, Texas, USA., Fowler RA; University of Toronto, Toronto, Canada., Goligher EC; University of Toronto, Toronto, Canada., Green C; Monash University, Melbourne, Australia., Haniffa R; University of Oxford, Bangkok, Thailand., Harrison DA; Intensive Care National Audit & Research Centre (ICNARC), London, UK., Hays LMC; University College Dublin Clinical Research Centre, St Vincent's University Hospital, Dublin, Ireland., Higgins AM; Monash University, Melbourne, Australia., Hills T; Medical Research Institute of New Zealand (MRINZ), Wellington, New Zealand., Horvat CM; University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pennsylvania, USA., Huang DT; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hunt BJ; Kings Healthcare Partners, London, UK., Ichihara N; The University of Tokyo, Tokyo, Japan., Jayakumar D; Apollo Speciality Hospital - Old Mahabalipuram Road, Chennai, India., Keattch S; Intensive Care National Audit & Research Centre (ICNARC), London, UK., Kumar A; University of Manitoba, Winnipeg, Canada., Laffan MA; Imperial College London, London, UK., Lamontagne F; Université de Sherbrooke, Sherbrooke, Canada., Leeper CM; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lewis RJ; Berry Consultants, Austin, Texas, USA., Lorenzi E; Berry Consultants, Austin, Texas, USA., Lother SA; University of Manitoba, Winnipeg, Canada., Marshall JC; St. Michael's Hospital Unity Health, Toronto, Canada., McArthur CJ; Auckland City Hospital, Auckland, New Zealand., McAuley DF; Queen's University Belfast, Belfast, Northern Ireland, UK., McGlothlin A; Berry Consultants, Austin, Texas, USA., McGuinness SP; Monash University, Melbourne, Australia., McQuilten ZK; Monash University, Melbourne, Australia., Middeldorp S; Radboud University Medical Center, Nijmegen, the Netherlands., Morpeth S; Middlemore Hospital, Auckland, New Zealand., Mouncey PR; Intensive Care National Audit & Research Centre (ICNARC), London, UK., Murthy S; University of British Columbia, Vancouver, Canada., Neal MD; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Nichol AD; University College Dublin, Clinical Research Centre at St Vincent's University Hospital, Dublin, Ireland., Parke RL; Auckland City Hospital, Auckland, New Zealand., Parker JC; Monash University, Melbourne, Australia., Peters S; European Clinical Research Alliance on Infectious Diseases (ECRAID), Utrecht, the Netherlands., Reyes LF; Universidad de La Sabana, Chia, Colombia., Rowan K; Intensive Care National Audit & Research Centre (ICNARC), London, UK., Saito H; St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan., Santos M; St. Michael's Hospital Unity Health, Toronto, Canada., Saunders CT; Berry Consultants, Austin, Texas, USA., Schutgens REG; University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Seymour CW; University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hari MS; King's College London, London, UK., Singh V; Monash University, Melbourne, Australia., Stanworth SJ; Oxford University, Oxford, UK., Turgeon AF; Université Laval, Québec City, Canada., Turner AM; Medical Research Institute of New Zealand (MRINZ), Wellington, New Zealand., van de Veerdonk FL; Radboud University Medical Center, Nijmegen, the Netherlands., Gordon AC; Imperial College London, London, UK; Imperial College Healthcare National Health Service Trust, St. Mary's Hospital, London, UK., Webb SA; Monash University, Melbourne, Australia., Zarychanski R; University of Manitoba, Winnipeg, Canada; CancerCare Manitoba, Winnipeg, Canada.
Corporate Authors: Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Investigators
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2026 Jul; Vol. 24 (7), pp. 2492-2505. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Adaptive Clinical Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Intermediate dose heparin thromboprophylaxis among critically ill patients with COVID-19: a randomized clinical trial.
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          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1538-7836
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Journal of thrombosis and haemostasis : JTH
              Type: main
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