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Liver-directed AAV-IL-10 therapy enhances CD8+ T cell-mediated immunity against hepatocellular carcinoma.

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Title: Liver-directed AAV-IL-10 therapy enhances CD8+ T cell-mediated immunity against hepatocellular carcinoma.
Authors: Lin CI; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan., Chiu YW; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan., Yen MS; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan., Wang YW; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan., Wu YH; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan., Chuang YH; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan yahuichuang@ntu.edu.tw.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Mar 27; Vol. 14 (3). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41895716
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Liver-directed AAV-IL-10 therapy enhances CD8<superscript>+</superscript> T cell-mediated immunity against hepatocellular carcinoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Lin+CI%22">Lin CI</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+YW%22">Chiu YW</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+MS%22">Yen MS</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YW%22">Wang YW</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YH%22">Wu YH</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+YH%22">Chuang YH</searchLink>; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan yahuichuang@ntu.edu.tw.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Mar 27; Vol. 14 (3). <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: Journal Article
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41895716
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1136/jitc-2025-012460
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Liver-directed AAV-IL-10 therapy enhances CD8+ T cell-mediated immunity against hepatocellular carcinoma.
        Type: main
  BibRelationships:
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      – PersonEntity:
          Name:
            NameFull: Lin CI
      – PersonEntity:
          Name:
            NameFull: Chiu YW
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            NameFull: Yen MS
      – PersonEntity:
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            NameFull: Wang YW
      – PersonEntity:
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            NameFull: Wu YH
      – PersonEntity:
          Name:
            NameFull: Chuang YH
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      – BibEntity:
          Dates:
            – D: 27
              M: 03
              Text: 2026 Mar 27
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2051-1426
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Journal for immunotherapy of cancer
              Type: main
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