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Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.

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Title: Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.
Authors: Kim HI; Pfizer Research and Development, Pfizer, Cambridge, MA, USA. hyein.kim@pfizer.com., DeBoever C; Maze Therapeutics, South San Francisco, CA, USA., Walter K; Wellcome Sanger Institute, Hinxton, UK., Kalantzis G; Wellcome Sanger Institute, Hinxton, UK., Li C; Informatics and Predictive Sciences, Research and Development, Bristol-Myers Squibb, Cambridge, MA, USA., Mozaffari SV; Maze Therapeutics, South San Francisco, CA, USA., Kundu K; Centre for Genomics Research, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Jacobs BM; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Mohammadi-Shemirani P; Takeda Development Center Americas, Inc., Cambridge, MA, USA., Musolf AM; Precision Genetics, Data AI and Genome Sciences, Merck & Co., Inc., Cambridge, MA, USA., Davitte JM; GSK, Collegeville, PA, USA., Aksit MA; Pfizer Research and Development, Pfizer, Cambridge, MA, USA., Gafton J; Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Blizard Institute, Queen Mary University of London, London, UK., Catalano KA; Informatics and Predictive Sciences, Research and Development, Bristol-Myers Squibb, Cambridge, MA, USA., Dawed AY; Novo Nordisk, Oxford, UK., Graham RR; Maze Therapeutics, South San Francisco, CA, USA., Guo B; Precision Genetics, Data AI and Genome Sciences, Merck & Co., Inc., Cambridge, MA, USA., Gupta N; Broad Clinical Labs, The Broad Institute, Cambridge, MA, USA., Heng TH; Wellcome Sanger Institute, Hinxton, UK., Hunt KA; Blizard Institute, Queen Mary University of London, London, UK., Iyer V; Wellcome Sanger Institute, Hinxton, UK., Langenberg C; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Lassen FH; Centre for Human Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., MacArthur DG; Centre for Population Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Maher ER; Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, UK., Maroteau C; Novo Nordisk, Oxford, UK., Newman WG; Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, NIHR Biomedical Research Centre, Manchester, UK.; Division of Evolution, Infection and Genomics, University of Manchester, Manchester, UK., O'Rahilly S; MRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Palmer DS; Department of Statistics, University of Oxford, Oxford, UK.; The Pioneer Centre for SMARTbiomed, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Popov I; Wellcome Sanger Institute, Hinxton, UK., Siddiqui MK; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Simpson MA; Faculty of Life Sciences and Medicine, King's College London, London, UK., Spreckley M; Blizard Institute, Queen Mary University of London, London, UK., Wright J; Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service Foundation Trust, Bradford, UK., Del Angel G; Centre for Genomics Research, Biopharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Petrovski S; Centre for Genomics Research, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Holzinger ER; Informatics and Predictive Sciences, Research and Development, Bristol-Myers Squibb, Cambridge, MA, USA., Maranville JC; Informatics and Predictive Sciences, Research and Development, Bristol-Myers Squibb, Cambridge, MA, USA., Addis L; GSK, Stevenage, UK., Turner RM; GSK, Stevenage, UK., Estrada K; Maze Therapeutics, South San Francisco, CA, USA., Longerich S; Precision Genetics, Data AI and Genome Sciences, Merck & Co., Inc., Cambridge, MA, USA., Howson JMM; Novo Nordisk, Oxford, UK., Jamshidi Y; Novo Nordisk, Oxford, UK., Fauman EB; Pfizer Research and Development, Pfizer, Cambridge, MA, USA., Miller MR; Pfizer Research and Development, Pfizer, Cambridge, MA, USA., Diogo D; Takeda Development Center Americas, Inc., Cambridge, MA, USA., Trembath RC; Faculty of Life Sciences and Medicine, King's College London, London, UK., Finer S; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Martin HC; Wellcome Sanger Institute, Hinxton, UK. hcm@sanger.ac.uk., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK. d.vanheel@qmul.ac.uk.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK. d.vanheel@qmul.ac.uk.
Corporate Authors: Genes and Health Research Team
Source: Nature genetics [Nat Genet] 2026 Apr; Vol. 58 (4), pp. 821-830. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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