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From empirical caution to precision resumption: model-informed management of a binimetinib overdose in a frail elderly patient.

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Title: From empirical caution to precision resumption: model-informed management of a binimetinib overdose in a frail elderly patient.
Authors: Sayadi H; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France., Fromage Y; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Inserm CIC 1435, CHU Dupuytren, Limoges, France., Labriffe M; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France., Monchaud C; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France., Jourdain H; Department of Dermatology, CHU Limoges, Limoges, France., Géniaux H; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France., Woillard JB; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France. jean-baptiste.woillard@unilim.fr.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France. jean-baptiste.woillard@unilim.fr.
Source: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2026 Mar 28; Vol. 82 (4). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article; Case Reports; Letter
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 1256165 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1041 (Electronic) Linking ISSN: 00316970 NLM ISO Abbreviation: Eur J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: From empirical caution to precision resumption: model-informed management of a binimetinib overdose in a frail elderly patient.
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  Data: <searchLink fieldCode="AU" term="%22Sayadi+H%22">Sayadi H</searchLink>; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France.<br /><searchLink fieldCode="AU" term="%22Fromage+Y%22">Fromage Y</searchLink>; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Inserm CIC 1435, CHU Dupuytren, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Labriffe+M%22">Labriffe M</searchLink>; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France.<br /><searchLink fieldCode="AU" term="%22Monchaud+C%22">Monchaud C</searchLink>; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France.<br /><searchLink fieldCode="AU" term="%22Jourdain+H%22">Jourdain H</searchLink>; Department of Dermatology, CHU Limoges, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Géniaux+H%22">Géniaux H</searchLink>; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France.<br /><searchLink fieldCode="AU" term="%22Woillard+JB%22">Woillard JB</searchLink>; Department of Pharmacology, Toxicology and Pharmacovigilance, Dupuytren University Hospital (CHU Dupuytren), Limoges, France. jean-baptiste.woillard@unilim.fr.; Pharmacology & Transplantation, INSERM U1248, University of Limoges, 2 rue du Pr Descottes, Limoges, F-87000, France. jean-baptiste.woillard@unilim.fr.
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  Data: <searchLink fieldCode="JN" term="%221256165%22">European journal of clinical pharmacology</searchLink> [Eur J Clin Pharmacol] 2026 Mar 28; Vol. 82 (4). <i>Date of Electronic Publication: </i>2026 Mar 28.
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