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PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example.

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Title: PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example.
Authors: Salem F; DMPK Modelling, DMPK, GSK, Stevenage, UK., Tabatabaeian Nimavardi A; Certara UK Limited, Simcyp Division, 1 Concourse Way, Level 2 Acero, Sheffield, UK., Srivastava A; Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, CB2 0AA, UK., Krollik K; Global Drug Product Development, the healthcare business of Merck KGaA, Darmstadt, Germany., Reichel A; Preclinical Modeling & Simulation, Pharma R&D, Bayer AG, Berlin, Germany., Cebrian D; Integrated Drug Discovery, Selvita SA, Podole 79, 30-394, Kraków, Poland., Taskar KS; DMPK Modelling, DMPK, GSK, Stevenage, UK., Yates JWT; DMPK Modelling, DMPK, GSK, Stevenage, UK., Rynn C; Translational PKPD and Clinical Pharmacology, Roche Products Ltd, Hexagon Place, 6 Falcon Way, Welwyn Garden City, UK., Duevel HM; NCE DMPK, the healthcare business of Merck KGaA, Darmstadt, Germany. heide.duevel@merckgroup.com.
Source: The AAPS journal [AAPS J] 2026 Mar 27; Vol. 28 (3). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example.
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  Data: <searchLink fieldCode="AU" term="%22Salem+F%22">Salem F</searchLink>; DMPK Modelling, DMPK, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Tabatabaeian+Nimavardi+A%22">Tabatabaeian Nimavardi A</searchLink>; Certara UK Limited, Simcyp Division, 1 Concourse Way, Level 2 Acero, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Srivastava+A%22">Srivastava A</searchLink>; Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, CB2 0AA, UK.<br /><searchLink fieldCode="AU" term="%22Krollik+K%22">Krollik K</searchLink>; Global Drug Product Development, the healthcare business of Merck KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Reichel+A%22">Reichel A</searchLink>; Preclinical Modeling & Simulation, Pharma R&D, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Cebrian+D%22">Cebrian D</searchLink>; Integrated Drug Discovery, Selvita SA, Podole 79, 30-394, Kraków, Poland.<br /><searchLink fieldCode="AU" term="%22Taskar+KS%22">Taskar KS</searchLink>; DMPK Modelling, DMPK, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Yates+JWT%22">Yates JWT</searchLink>; DMPK Modelling, DMPK, GSK, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Rynn+C%22">Rynn C</searchLink>; Translational PKPD and Clinical Pharmacology, Roche Products Ltd, Hexagon Place, 6 Falcon Way, Welwyn Garden City, UK.<br /><searchLink fieldCode="AU" term="%22Duevel+HM%22">Duevel HM</searchLink>; NCE DMPK, the healthcare business of Merck KGaA, Darmstadt, Germany. heide.duevel@merckgroup.com.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 Mar 27; Vol. 28 (3). <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE
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        Value: 10.1208/s12248-026-01231-0
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              Text: 2026 Mar 27
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