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Therapeutic potential of cAMP-mediated lysosomal pH modulation in ATP6V1B2-related neuropathology.

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Title: Therapeutic potential of cAMP-mediated lysosomal pH modulation in ATP6V1B2-related neuropathology.
Authors: Zheng L; School of Medicine, Nankai University, Tianjin, China.; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China.; State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China., Zhao W; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China.; State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China., Yang G; Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing, China.; Senior Department of Pediatrics, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China., Qiu S; School of Life Sciences, Tsinghua University, Beijing, China.; Chinese Institute for Brain Research, Beijing, China., Li Y; Chinese Institute for Brain Research, Beijing, China., Gao L; Department of Automation, Tsinghua University, Beijing, China., Wei G; Chinese Institute for Brain Research, Beijing, China., Ma Y; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China.; State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China., Xie J; Chinese Institute for Brain Research, Beijing, China., Gao X; Chinese Institute for Brain Research, Beijing, China., Chen L; Chinese Institute for Brain Research, Beijing, China., Li X; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China.; State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China., Lin R; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China.; State Key Laboratory of Hearing and Balance Science, Beijing, China.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China., Xiong W; Chinese Institute for Brain Research, Beijing, China. wei_xiong@cibr.ac.cn., Yuan Y; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China. yyymzh@163.com.; State Key Laboratory of Hearing and Balance Science, Beijing, China. yyymzh@163.com.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China. yyymzh@163.com.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China. yyymzh@163.com.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China. yyymzh@163.com., Dai P; School of Medicine, Nankai University, Tianjin, China. daipu301@vip.sina.com.; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China. daipu301@vip.sina.com.; State Key Laboratory of Hearing and Balance Science, Beijing, China. daipu301@vip.sina.com.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China. daipu301@vip.sina.com.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China. daipu301@vip.sina.com.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China. daipu301@vip.sina.com.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 27; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
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Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+G%22">Yang G</searchLink>; Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing, China.; Senior Department of Pediatrics, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Qiu+S%22">Qiu S</searchLink>; School of Life Sciences, Tsinghua University, Beijing, China.; Chinese Institute for Brain Research, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Chinese Institute for Brain Research, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Department of Automation, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wei+G%22">Wei G</searchLink>; Chinese Institute for Brain Research, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; 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Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China. yyymzh@163.com.; State Key Laboratory of Hearing and Balance Science, Beijing, China. yyymzh@163.com.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China. yyymzh@163.com.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China. yyymzh@163.com.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China. yyymzh@163.com.<br /><searchLink fieldCode="AU" term="%22Dai+P%22">Dai P</searchLink>; School of Medicine, Nankai University, Tianjin, China. daipu301@vip.sina.com.; Senior Department of Otolaryngology Head and Neck Surgery, The 6th Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, China. daipu301@vip.sina.com.; State Key Laboratory of Hearing and Balance Science, Beijing, China. daipu301@vip.sina.com.; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China. daipu301@vip.sina.com.; Key Laboratory of Hearing Science, Ministry of Education, Beijing, China. daipu301@vip.sina.com.; Beijing Key Laboratory of Hearing Impairment Prevention and Treatment, Beijing, China. daipu301@vip.sina.com.
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        Value: 10.1038/s41420-026-03056-4
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              Text: 2026 Mar 27
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