A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP.

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Title: A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP.
Authors: Maldosevic E; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Gora RJ; Division of Chemistry and Chemical Engineering, Caltech, Pasadena, CA, USA., Lin LL; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Zhou LE; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Li ZJ; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.; Medical Scientist Training Program, University of Virginia, School of Medicine, Charlottesville, VA, USA., Peskova Y; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Qi L; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA., Shan SO; Division of Chemistry and Chemical Engineering, Caltech, Pasadena, CA, USA. sshan@caltech.edu., Jomaa A; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. ahmadjomaa@virginia.edu.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA. ahmadjomaa@virginia.edu.
Source: Nature communications [Nat Commun] 2026 Mar 27; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Maldosevic+E%22">Maldosevic E</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Gora+RJ%22">Gora RJ</searchLink>; Division of Chemistry and Chemical Engineering, Caltech, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+LL%22">Lin LL</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+LE%22">Zhou LE</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Li+ZJ%22">Li ZJ</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.; Medical Scientist Training Program, University of Virginia, School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Peskova+Y%22">Peskova Y</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Qi+L%22">Qi L</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Shan+SO%22">Shan SO</searchLink>; Division of Chemistry and Chemical Engineering, Caltech, Pasadena, CA, USA. sshan@caltech.edu.<br /><searchLink fieldCode="AU" term="%22Jomaa+A%22">Jomaa A</searchLink>; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. ahmadjomaa@virginia.edu.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA. ahmadjomaa@virginia.edu.
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        Value: 10.1038/s41467-026-71061-3
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              Text: 2026 Mar 27
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