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The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis.

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Title: The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis.
Authors: Sillassen CDB; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark. christina.sillassen@ctu.dk.; Department of Cardiology, Central and West Zealand Hospital, Region of Zealand, Slagelse, Denmark. christina.sillassen@ctu.dk.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. christina.sillassen@ctu.dk., Faltermeier P; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Bjerg JL; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark., Andersen RK; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark., Petersen JJ; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark., Andersen PB; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; The Technical University of Denmark, Kgs. Lyngby, Denmark., Kamp CB; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark., Karlsson F; Department of Clinical Sciences, Lund University, Malmö, Sweden., Grand J; Department of Cardiology, Copenhagen University Hospital - Amager-Hvidovre Hospital, Copenhagen, Denmark., Dominguez H; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark., Frølich A; Innovation and Research Centre for Multimorbidity, Central and West Zealand Hospital, Region of Zealand, Slagelse, Denmark.; Section of General Practice, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gæde P; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.; Department of Internal Medicine, Geriatrics and Neurology, M3, Central and West Zealand Hospital, Slagelse, Denmark., Gluud C; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Mathiesen O; Department of Anesthesiology, Centre for Anesthesiologic Research, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark., Jakobsen JC; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Source: BMC medicine [BMC Med] 2026 Mar 27; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 27.
Publication Type: Systematic Review; Journal Article; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Sillassen+CDB%22">Sillassen CDB</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark. christina.sillassen@ctu.dk.; Department of Cardiology, Central and West Zealand Hospital, Region of Zealand, Slagelse, Denmark. christina.sillassen@ctu.dk.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. christina.sillassen@ctu.dk.<br /><searchLink fieldCode="AU" term="%22Faltermeier+P%22">Faltermeier P</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Bjerg+JL%22">Bjerg JL</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+RK%22">Andersen RK</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+JJ%22">Petersen JJ</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+PB%22">Andersen PB</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; The Technical University of Denmark, Kgs. Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Kamp+CB%22">Kamp CB</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Karlsson+F%22">Karlsson F</searchLink>; Department of Clinical Sciences, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Grand+J%22">Grand J</searchLink>; Department of Cardiology, Copenhagen University Hospital - Amager-Hvidovre Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dominguez+H%22">Dominguez H</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Frølich+A%22">Frølich A</searchLink>; Innovation and Research Centre for Multimorbidity, Central and West Zealand Hospital, Region of Zealand, Slagelse, Denmark.; Section of General Practice, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gæde+P%22">Gæde P</searchLink>; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.; Department of Internal Medicine, Geriatrics and Neurology, M3, Central and West Zealand Hospital, Slagelse, Denmark.<br /><searchLink fieldCode="AU" term="%22Gluud+C%22">Gluud C</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Mathiesen+O%22">Mathiesen O</searchLink>; Department of Anesthesiology, Centre for Anesthesiologic Research, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+JC%22">Jakobsen JC</searchLink>; Centre for Clinical Intervention Research, Copenhagen Trial Unit, Copenhagen University Hospital - Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
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