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Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans.

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Title: Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans.
Authors: Kar A; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA., Lee SHT; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Alvarez M; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Rajkumar S; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Das SS; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Ochoa-Guzmán A; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Muñoz-Hernandez LL; Unidad de Investigación de Enfermedades Metabólicas of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Consejo Nacional de Ciencia y Tecnología, Mexico City, Mexico., Guillen-Quintero DM; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Herrera-Hernandez M; Surgery Direction of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Cruz-Bautista I; Unidad de Investigación de Enfermedades Metabólicas of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Heinonen S; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Saarinen T; Department of Abdominal Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Juuti A; Department of Abdominal Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Laakso M; Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Healthy Weight Hub, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Balliu B; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Aguilar-Salinas C; Unidad de Investigación de Enfermedades Metabólicas of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Tecnológico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Mexico City, México., Tusié-Luna MT; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ppajukanta@mednet.ucla.edu.; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA. ppajukanta@mednet.ucla.edu.; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ppajukanta@mednet.ucla.edu.
Source: Genome medicine [Genome Med] 2026 Mar 28; Vol. 18 (1). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
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  Data: Lessons from single cell omics: admixed American ancestry and sex confer cardiometabolic disease risk in Mexicans.
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  Data: <searchLink fieldCode="AU" term="%22Kar+A%22">Kar A</searchLink>; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+SHT%22">Lee SHT</searchLink>; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez+M%22">Alvarez M</searchLink>; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rajkumar+S%22">Rajkumar S</searchLink>; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Das+SS%22">Das SS</searchLink>; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ochoa-Guzmán+A%22">Ochoa-Guzmán A</searchLink>; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Muñoz-Hernandez+LL%22">Muñoz-Hernandez LL</searchLink>; Unidad de Investigación de Enfermedades Metabólicas of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Consejo Nacional de Ciencia y Tecnología, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Guillen-Quintero+DM%22">Guillen-Quintero DM</searchLink>; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Herrera-Hernandez+M%22">Herrera-Hernandez M</searchLink>; Surgery Direction of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Cruz-Bautista+I%22">Cruz-Bautista I</searchLink>; Unidad de Investigación de Enfermedades Metabólicas of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Heinonen+S%22">Heinonen S</searchLink>; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Saarinen+T%22">Saarinen T</searchLink>; Department of Abdominal Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Juuti+A%22">Juuti A</searchLink>; Department of Abdominal Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Pietiläinen+KH%22">Pietiläinen KH</searchLink>; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Healthy Weight Hub, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Balliu+B%22">Balliu B</searchLink>; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Aguilar-Salinas+C%22">Aguilar-Salinas C</searchLink>; Unidad de Investigación de Enfermedades Metabólicas of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Tecnológico de Monterrey, Escuela de Medicina y Ciencias de La Salud, Mexico City, México.<br /><searchLink fieldCode="AU" term="%22Tusié-Luna+MT%22">Tusié-Luna MT</searchLink>; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Pajukanta+P%22">Pajukanta P</searchLink>; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ppajukanta@mednet.ucla.edu.; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA. ppajukanta@mednet.ucla.edu.; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ppajukanta@mednet.ucla.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101475844 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-994X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221756994X%22">1756994X </searchLink><i>NLM ISO Abbreviation: </i>Genome Med <i>Subsets: </i>MEDLINE
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