Hypomorphic Protein Expression of DNA Polymerase Beta in PolβL301R-V303R/L301R-V303R Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain.
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| Title: | Hypomorphic Protein Expression of DNA Polymerase Beta in PolβL301R-V303R/L301R-V303R Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain. |
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| Authors: | Jacobs B; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Ivanov D; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Barraza I; Departments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA., Faulk C; Department of Animal Sciences, University of Minnesota, Minneapolis, MN 55455, USA., Booth CJ; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Mattos-Canedo R; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Tian L; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., DePietro K; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Uzun A; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Roos WP; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Sanders LH; Departments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA., Sobol RW; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA. |
| Source: | Biomolecules [Biomolecules] 2026 Mar 11; Vol. 16 (3). Date of Electronic Publication: 2026 Mar 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2218-273X |
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| DOI: | 10.3390/biom16030412 |