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Hypomorphic Protein Expression of DNA Polymerase Beta in PolβL301R-V303R/L301R-V303R Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain.

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Title: Hypomorphic Protein Expression of DNA Polymerase Beta in PolβL301R-V303R/L301R-V303R Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain.
Authors: Jacobs B; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Ivanov D; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Barraza I; Departments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA., Faulk C; Department of Animal Sciences, University of Minnesota, Minneapolis, MN 55455, USA., Booth CJ; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Mattos-Canedo R; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Tian L; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., DePietro K; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Uzun A; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Roos WP; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA., Sanders LH; Departments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA., Sobol RW; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.
Source: Biomolecules [Biomolecules] 2026 Mar 11; Vol. 16 (3). Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ<superscript>L301R-V303R/L301R-V303R</superscript> Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain.
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  Data: <searchLink fieldCode="AU" term="%22Jacobs+B%22">Jacobs B</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22Ivanov+D%22">Ivanov D</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22Barraza+I%22">Barraza I</searchLink>; Departments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Faulk+C%22">Faulk C</searchLink>; Department of Animal Sciences, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Booth+CJ%22">Booth CJ</searchLink>; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Mattos-Canedo+R%22">Mattos-Canedo R</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22Tian+L%22">Tian L</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22DePietro+K%22">DePietro K</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22Uzun+A%22">Uzun A</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22Roos+WP%22">Roos WP</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+LH%22">Sanders LH</searchLink>; Departments of Neurology and Pathology, Duke University, Durham, NC 27708, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Sobol+RW%22">Sobol RW</searchLink>; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.
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  Data: <searchLink fieldCode="JN" term="%22101596414%22">Biomolecules</searchLink> [Biomolecules] 2026 Mar 11; Vol. 16 (3). <i>Date of Electronic Publication: </i>2026 Mar 11.
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