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Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis.

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Title: Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis.
Authors: Fraj E; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Elbouzidi A; Laboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Bouammali H; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Jaouani H; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Bourhou C; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Addi M; Laboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Zughaier SM; College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar., Challioui A; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Touzani R; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco., Bouammali B; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.
Source: Current issues in molecular biology [Curr Issues Mol Biol] 2026 Feb 25; Vol. 48 (3). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100931761 Publication Model: Electronic Cited Medium: Internet ISSN: 1467-3045 (Electronic) Linking ISSN: 14673037 NLM ISO Abbreviation: Curr Issues Mol Biol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Fraj+E%22">Fraj E</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Elbouzidi+A%22">Elbouzidi A</searchLink>; Laboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Bouammali+H%22">Bouammali H</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Jaouani+H%22">Jaouani H</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Bourhou+C%22">Bourhou C</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Addi+M%22">Addi M</searchLink>; Laboratory for Agricultural Production Improvement, Biotechnology, and Environment (LAPABE), Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Zughaier+SM%22">Zughaier SM</searchLink>; College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.<br /><searchLink fieldCode="AU" term="%22Challioui+A%22">Challioui A</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Touzani+R%22">Touzani R</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.<br /><searchLink fieldCode="AU" term="%22Bouammali+B%22">Bouammali B</searchLink>; Laboratory of applied Chemistry and Environment, Faculty of Sciences, Mohammed First University, Oujda 60000, Morocco.
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  Data: <searchLink fieldCode="JN" term="%22100931761%22">Current issues in molecular biology</searchLink> [Curr Issues Mol Biol] 2026 Feb 25; Vol. 48 (3). <i>Date of Electronic Publication: </i>2026 Feb 25.
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              Text: 2026 Feb 25
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