Arecoline as a Novel Scaffold Targeting the ATAD2 Bromodomain for Cell Cycle Modulation.

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Title: Arecoline as a Novel Scaffold Targeting the ATAD2 Bromodomain for Cell Cycle Modulation.
Authors: Lin TS; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China., Wan J; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China., He J; Department of General Practice, Shenzhen Luohu People's Hospital, Shenzhen 518000, China.; Luohu Clinical College, Shantou University Medical College, Shenzhen 518000, China., Cui S; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China., Huang Y; Department of General Practice, Shenzhen Luohu People's Hospital, Shenzhen 518000, China.; Luohu Clinical College, Shantou University Medical College, Shenzhen 518000, China., Zhang B; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China., Huang HY; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China., Zhu K; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China., Chen J; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China., Zhang T; Better Way Group-Chinese University of Hong Kong (Shenzhen) Warshel Joint Laboratory for Skin Health and Active Molecule Innovation, Shenzhen 518172, China., Li S; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China., Hu L; Department of Electrical & Computer Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA., Wang Y; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China., Huang HD; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China.; Better Way Group-Chinese University of Hong Kong (Shenzhen) Warshel Joint Laboratory for Skin Health and Active Molecule Innovation, Shenzhen 518172, China.; Department of Endocrinology, Key Laboratory of Endocrinology of National Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China., Tang P; Department of General Practice, Shenzhen Luohu People's Hospital, Shenzhen 518000, China.; Luohu Clinical College, Shantou University Medical College, Shenzhen 518000, China., Lin YC; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Guangdong Provincial Key Laboratory of Digital Biology and Drug Development, The Chinese University of Hong Kong, Shenzhen 518172, China.; Better Way Group-Chinese University of Hong Kong (Shenzhen) Warshel Joint Laboratory for Skin Health and Active Molecule Innovation, Shenzhen 518172, China.
Source: Pharmaceutics [Pharmaceutics] 2026 Mar 03; Vol. 18 (3). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1999-4923
DOI:10.3390/pharmaceutics18030324