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Innovative Nanocarriers: Elastic Aspasomes Loaded with Metformin Hydrochloride for Effective Management of Melasma: In Vitro Studies and Clinical Appraisal.

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Title: Innovative Nanocarriers: Elastic Aspasomes Loaded with Metformin Hydrochloride for Effective Management of Melasma: In Vitro Studies and Clinical Appraisal.
Authors: Albash R; Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza 12568, Egypt., Fahmy AM; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 12613, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11865, Egypt., Ragaie MH; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya 61111, Egypt., Ahmed SS; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya 61111, Egypt., El-Gazar RA; Department of Clinical Pharmacy, October 6 University, Giza 12585, Egypt., Kassem AB; Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Damanhour University, Damanhour 22514, Egypt., Abdelbari MA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt., Salem HA; Pharmacy Practice Department, University of Tabuk, Tabuk 71491, Saudi Arabia., Saleh A; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Mosallam S; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.
Source: Pharmaceutics [Pharmaceutics] 2026 Mar 14; Vol. 18 (3). Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Innovative Nanocarriers: Elastic Aspasomes Loaded with Metformin Hydrochloride for Effective Management of Melasma: In Vitro Studies and Clinical Appraisal.
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  Data: <searchLink fieldCode="AU" term="%22Albash+R%22">Albash R</searchLink>; Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza 12568, Egypt.<br /><searchLink fieldCode="AU" term="%22Fahmy+AM%22">Fahmy AM</searchLink>; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 12613, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, Cairo 11865, Egypt.<br /><searchLink fieldCode="AU" term="%22Ragaie+MH%22">Ragaie MH</searchLink>; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya 61111, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+SS%22">Ahmed SS</searchLink>; Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya 61111, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Gazar+RA%22">El-Gazar RA</searchLink>; Department of Clinical Pharmacy, October 6 University, Giza 12585, Egypt.<br /><searchLink fieldCode="AU" term="%22Kassem+AB%22">Kassem AB</searchLink>; Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Damanhour University, Damanhour 22514, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelbari+MA%22">Abdelbari MA</searchLink>; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.<br /><searchLink fieldCode="AU" term="%22Salem+HA%22">Salem HA</searchLink>; Pharmacy Practice Department, University of Tabuk, Tabuk 71491, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Saleh+A%22">Saleh A</searchLink>; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Mosallam+S%22">Mosallam S</searchLink>; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza 12585, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101534003%22">Pharmaceutics</searchLink> [Pharmaceutics] 2026 Mar 14; Vol. 18 (3). <i>Date of Electronic Publication: </i>2026 Mar 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI%22">MDPI </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101534003 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1999-4923 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219994923%22">19994923 </searchLink><i>NLM ISO Abbreviation: </i>Pharmaceutics <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.3390/pharmaceutics18030364
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      – Code: eng
        Text: English
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      – TitleFull: Innovative Nanocarriers: Elastic Aspasomes Loaded with Metformin Hydrochloride for Effective Management of Melasma: In Vitro Studies and Clinical Appraisal.
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              Text: 2026 Mar 14
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