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Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence.

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Title: Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence.
Authors: Chaúque BJM; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.; Center of Studies in Science and Technology (NECET), Biology Course, Universidade Rovuma, Lichinga P.O. Box 04, Niassa, Mozambique., Chagas LB; Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., da Silva TCB; Protozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Dos Santos DL; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil., Rodrigues LP; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.; Physiotherapy Course, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Baía LDSL; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Rodrigues MKG; School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90610-970, RS, Brazil., Benitez GB; Industrial and Systems Engineering Graduate Program, Polytechnic School, Pontifical Catholic University of Parana (PUCPR), Curitiba 80215-901, PR, Brazil., Mendes TL; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Philippsen HK; Socio-Environmental and Water Resources Institute, Federal Rural University of the Amazon (UFRA), Belém 66077-830, PA, Brazil., Rosa LD; Central Laboratory for Avian Disease Diagnosis, Department of Preventive Veterinary Medicine, Center for Rural Sciences, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil ., Campos FS; Laboratório de Bioinformática & Biotecnologia, Instituto de Ciências Básicas da Saúde, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.; Department of Public & Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA., Rott MB; Protozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Zanette RA; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Goldim JR; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
Source: Pathogens (Basel, Switzerland) [Pathogens] 2026 Mar 07; Vol. 15 (3). Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article; Systematic Review; Review
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Promising Drug Repurposing Candidates Targeting Free-Living Amoebae: A Systematic and Critical Review of Laboratory-Based Evidence.
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  Data: <searchLink fieldCode="AU" term="%22Chaúque+BJM%22">Chaúque BJM</searchLink>; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.; Center of Studies in Science and Technology (NECET), Biology Course, Universidade Rovuma, Lichinga P.O. Box 04, Niassa, Mozambique.<br /><searchLink fieldCode="AU" term="%22Chagas+LB%22">Chagas LB</searchLink>; Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+TCB%22">da Silva TCB</searchLink>; Protozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+DL%22">Dos Santos DL</searchLink>; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+LP%22">Rodrigues LP</searchLink>; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.; Physiotherapy Course, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Baía+LDSL%22">Baía LDSL</searchLink>; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+MKG%22">Rodrigues MKG</searchLink>; School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90610-970, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Benitez+GB%22">Benitez GB</searchLink>; Industrial and Systems Engineering Graduate Program, Polytechnic School, Pontifical Catholic University of Parana (PUCPR), Curitiba 80215-901, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendes+TL%22">Mendes TL</searchLink>; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Philippsen+HK%22">Philippsen HK</searchLink>; Socio-Environmental and Water Resources Institute, Federal Rural University of the Amazon (UFRA), Belém 66077-830, PA, Brazil.<br /><searchLink fieldCode="AU" term="%22Rosa+LD%22">Rosa LD</searchLink>; Central Laboratory for Avian Disease Diagnosis, Department of Preventive Veterinary Medicine, Center for Rural Sciences, Universidade Federal de Santa Maria, Santa Maria 97105-900, RS, Brazil .<br /><searchLink fieldCode="AU" term="%22Campos+FS%22">Campos FS</searchLink>; Laboratório de Bioinformática & Biotecnologia, Instituto de Ciências Básicas da Saúde, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.; Department of Public & Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.<br /><searchLink fieldCode="AU" term="%22Rott+MB%22">Rott MB</searchLink>; Protozoology Laboratory, Microbiology Immunology and Parasitology Department, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Zanette+RA%22">Zanette RA</searchLink>; Postgraduate Program in Biological Sciences-Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Goldim+JR%22">Goldim JR</searchLink>; Master's Program in Clinical Research, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-903, RS, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101596317%22">Pathogens (Basel, Switzerland)</searchLink> [Pathogens] 2026 Mar 07; Vol. 15 (3). <i>Date of Electronic Publication: </i>2026 Mar 07.
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        Value: 10.3390/pathogens15030294
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