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Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease and Early-Stage Renal Dysfunction in a Rodent Model.

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Title: Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease and Early-Stage Renal Dysfunction in a Rodent Model.
Authors: Chen YS; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institute, Miaoli County, Taiwan.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Lin HY; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Lin CT; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Huang SH; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Yeh ML; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan.; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Center of Hepatitis Research, College of Medicine and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Yu ML; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan.; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Center of Hepatitis Research, College of Medicine and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Lee JC; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung, Taiwan., Chung YC; Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan., Li WM; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Li CC; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Huang SF; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institute, Miaoli County, Taiwan., Yen CH; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institute, Miaoli County, Taiwan.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan.; Center of Hepatitis Research, College of Medicine and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Source: The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2026 Mar 28, pp. e70206. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Department of Public Health, Kaohsiung Medical University Country of Publication: China (Republic : 1949- ) NLM ID: 100960562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2410-8650 (Electronic) Linking ISSN: 1607551X NLM ISO Abbreviation: Kaohsiung J Med Sci Subsets: MEDLINE
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  Data: Chronic, Environmentally Relevant PM<subscript>2.5</subscript> Exposure Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease and Early-Stage Renal Dysfunction in a Rodent Model.
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  Data: <searchLink fieldCode="AU" term="%22Chen+YS%22">Chen YS</searchLink>; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institute, Miaoli County, Taiwan.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CT%22">Lin CT</searchLink>; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SH%22">Huang SH</searchLink>; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+ML%22">Yeh ML</searchLink>; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan.; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Center of Hepatitis Research, College of Medicine and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+ML%22">Yu ML</searchLink>; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan.; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; Center of Hepatitis Research, College of Medicine and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+JC%22">Lee JC</searchLink>; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.; Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chung+YC%22">Chung YC</searchLink>; Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+WM%22">Li WM</searchLink>; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+CC%22">Li CC</searchLink>; Department of Urology, Kaohsiung Medical University Gangshan Hospital, Kaohsiung, Taiwan.; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SF%22">Huang SF</searchLink>; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institute, Miaoli County, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+CH%22">Yen CH</searchLink>; Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University and National Health Research Institutes, Kaohsiung, Taiwan.; Institute of Molecular and Genomic Medicine, National Health Research Institute, Miaoli County, Taiwan.; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan.; Center of Hepatitis Research, College of Medicine and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
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