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Polyglutamine homorepeat regulates Runx2 condensation and cellular localization in a KPNA3-dependent manner.

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Title: Polyglutamine homorepeat regulates Runx2 condensation and cellular localization in a KPNA3-dependent manner.
Authors: Weng JH; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Xu SB; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: xushuibo@zju.edu.cn., Lv JC; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Li YY; School of Basic Medical Sciences, Henan University, Kaifeng 475004, China., Chen H; Center of Bone Metabolism and Repair, Laboratory of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China., Zhang TR; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Liang HD; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Chen RJ; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Chen L; Center of Bone Metabolism and Repair, Laboratory of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China., Chen X; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Ouyang H; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China., Zheng LL; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Hangzhou 310000, China., Shen W; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: wlshen@zju.edu.cn., Wu LD; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: wulidong@zju.edu.cn., Zhou YT; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Hangzhou 310000, China. Electronic address: zhouyt@zju.edu.cn.
Source: Cell reports [Cell Rep] 2026 Mar 27; Vol. 45 (4), pp. 117205. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Polyglutamine homorepeat regulates Runx2 condensation and cellular localization in a KPNA3-dependent manner.
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  Data: <searchLink fieldCode="AU" term="%22Weng+JH%22">Weng JH</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Xu+SB%22">Xu SB</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: xushuibo@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lv+JC%22">Lv JC</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Li+YY%22">Li YY</searchLink>; School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Center of Bone Metabolism and Repair, Laboratory of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China.<br /><searchLink fieldCode="AU" term="%22Zhang+TR%22">Zhang TR</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Liang+HD%22">Liang HD</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+RJ%22">Chen RJ</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Center of Bone Metabolism and Repair, Laboratory of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+H%22">Ouyang H</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.<br /><searchLink fieldCode="AU" term="%22Zheng+LL%22">Zheng LL</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Hangzhou 310000, China.<br /><searchLink fieldCode="AU" term="%22Shen+W%22">Shen W</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: wlshen@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+LD%22">Wu LD</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: wulidong@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+YT%22">Zhou YT</searchLink>; Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Hangzhou 310000, China. Electronic address: zhouyt@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Mar 27; Vol. 45 (4), pp. 117205. <i>Date of Electronic Publication: </i>2026 Mar 27.
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