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Lonp1 inhibition disrupts mitochondrial function in the hippocampus and drives an aging-like synaptic and cognitive phenotype in adult SAMP8 mice.

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Title: Lonp1 inhibition disrupts mitochondrial function in the hippocampus and drives an aging-like synaptic and cognitive phenotype in adult SAMP8 mice.
Authors: Cortés-Díaz D; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, Santiago, Chile., Jara C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile., Fuentes Í; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile., Llanquinao J; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile., Lira M; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile., Ricca M; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile., Valenzuela S; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile; Facultad de Medicina Veterinaria, Universidad San Sebastián, Bellavista 07, Recoleta, Santiago, Chile., Oliva CA; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile; Centro para la Transversalización de Género en I+D+i+e, Vicerrectoría de Investigación y Doctorados, Universidad Autónoma de Chile, Huechuraba, Santiago, Chile., Tapia-Rojas C; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, Santiago, Chile. Electronic address: cheril.tapia@uss.cl.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 Jul; Vol. 250, pp. 298-311. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lonp1 inhibition disrupts mitochondrial function in the hippocampus and drives an aging-like synaptic and cognitive phenotype in adult SAMP8 mice.
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  Data: <searchLink fieldCode="AU" term="%22Cortés-Díaz+D%22">Cortés-Díaz D</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Jara+C%22">Jara C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Fuentes+Í%22">Fuentes Í</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Llanquinao+J%22">Llanquinao J</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Lira+M%22">Lira M</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Ricca+M%22">Ricca M</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Valenzuela+S%22">Valenzuela S</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile; Facultad de Medicina Veterinaria, Universidad San Sebastián, Bellavista 07, Recoleta, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Oliva+CA%22">Oliva CA</searchLink>; Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida del Valle Norte 725, Huechuraba, Santiago, Chile; Centro para la Transversalización de Género en I+D+i+e, Vicerrectoría de Investigación y Doctorados, Universidad Autónoma de Chile, Huechuraba, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Tapia-Rojas+C%22">Tapia-Rojas C</searchLink>; Laboratory of Neurobiology of Aging, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Huechuraba, Santiago, Chile; Facultad de Ciencias, Universidad San Sebastián, Lota 2465, Santiago, Chile. Electronic address: cheril.tapia@uss.cl.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2026 Jul; Vol. 250, pp. 298-311. <i>Date of Electronic Publication: </i>2026 Mar 27.
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      – Code: eng
        Text: English
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        StartPage: 298
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      – TitleFull: Lonp1 inhibition disrupts mitochondrial function in the hippocampus and drives an aging-like synaptic and cognitive phenotype in adult SAMP8 mice.
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            NameFull: Cortés-Díaz D
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              Text: 2026 Jul
              Type: published
              Y: 2026
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