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Deltex E3 ubiquitin ligase 2 potentiates STING-mediated type I interferon response by K63-linked ubiquitination.

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Title: Deltex E3 ubiquitin ligase 2 potentiates STING-mediated type I interferon response by K63-linked ubiquitination.
Authors: Liu Z; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin; National Clinical Research Center for Cancer; Tianjin's Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University, Tianjin, China., Li R; Division of Medical Technology, Tianjin Medical University, Tianjin, China., Fan C; Division of Medical Technology, Tianjin Medical University, Tianjin, China., Liu Y; Division of Medical Technology, Tianjin Medical University, Tianjin, China., Liu J; Division of Medical Technology, Tianjin Medical University, Tianjin, China., Yin M; Division of Medical Technology, Tianjin Medical University, Tianjin, China., Shang N; Division of Medical Technology, Tianjin Medical University, Tianjin, China., Wang X; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin; National Clinical Research Center for Cancer; Tianjin's Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University, Tianjin, China. wxd.1133@163.com., Qi Z; Department of Molecular Pharmacology, School of Medicine; Beichen Hospital, Nankai University, Tianjin, China. qizhi@nankai.edu.cn.; Tianjin Key Laboratory of General Surgery in Construction, Tianjin Union Medical Center, Tianjin, China. qizhi@nankai.edu.cn.; The first Department of Critical Care Medicine, The first Affiliated Hospital of Shihezi University, Shihezi, China. qizhi@nankai.edu.cn., Shen Y; Division of Medical Technology, Tianjin Medical University, Tianjin, China. shenyanna@tmu.edu.cn., Liu C; Division of Medical Technology, Tianjin Medical University, Tianjin, China. liuchang419@tmu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 Mar 28; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deltex E3 ubiquitin ligase 2 potentiates STING-mediated type I interferon response by K63-linked ubiquitination.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin; National Clinical Research Center for Cancer; Tianjin's Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Fan+C%22">Fan C</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yin+M%22">Yin M</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Shang+N%22">Shang N</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Tianjin; National Clinical Research Center for Cancer; Tianjin's Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin Medical University, Tianjin, China. wxd.1133@163.com.<br /><searchLink fieldCode="AU" term="%22Qi+Z%22">Qi Z</searchLink>; Department of Molecular Pharmacology, School of Medicine; Beichen Hospital, Nankai University, Tianjin, China. qizhi@nankai.edu.cn.; Tianjin Key Laboratory of General Surgery in Construction, Tianjin Union Medical Center, Tianjin, China. qizhi@nankai.edu.cn.; The first Department of Critical Care Medicine, The first Affiliated Hospital of Shihezi University, Shihezi, China. qizhi@nankai.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China. shenyanna@tmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Division of Medical Technology, Tianjin Medical University, Tianjin, China. liuchang419@tmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Mar 28; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41904156
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        Value: 10.1038/s41419-026-08659-4
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            – D: 28
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              Text: 2026 Mar 28
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