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The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.

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Title: The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.
Authors: Wan J; Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Pan H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China., Chang D; Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Zhao Y; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Xu Q; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Yao L; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China., Sun Q; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, China., Zhang X; Department of Health Management Center, Xiangya Hospital, Central South University, Changsha, China., He R; Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China., Wang C; Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China., Zhang H; Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China., Lei L; Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China., Wang Y; Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Li M; Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Wu H; Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Ma J; Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, China., Wu Y; Department of Neurology, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Xu Y; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Xiong N; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang T; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang X; Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Chen L; Department of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China., Xu Y; Department of Neurology, West China Hospital, Sichuan University, Chengdu, China., Cao H; Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Zhang K; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Liu W; Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China., Zhang Y; Department of Neurology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China., Mao C; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China., Wang Q; Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China., Xue Z; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China., Cheng O; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Huang W; Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Zhao G; Department of Neurology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University, Jinhua, China., Cui G; Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Chen T; Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China., Wang P; Department of Neurology, Xiang Yang No. 1 People's Hospital Affiliated to Hubei University of Medicine, Xiangyang, China., Di W; Department of Neurology, Shaanxi Provincial People's Hospital, Xi'an, China., Liu H; Department of Neurology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China., Zheng H; Suzhou Laboratory of Precision Health and Data Science, The Second Affiliated Hospital of Soochow University, Suzhou, China., Chen C; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China., Guo H; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China., Xia K; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China., Zhang Z; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China., Yuan K; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Li J; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; The First Affiliated Hospital of Anhui Medical University, Hefei, China., Wang J; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Guo J; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Bioinformatics Center, Xiangya Hospital and Furong Laboratory, Central South University, Changsha, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China., Shen L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Bioinformatics Center, Xiangya Hospital and Furong Laboratory, Central South University, Changsha, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China., Jiang H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.; Bioinformatics Center, Xiangya Hospital and Furong Laboratory, Central South University, Changsha, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China., Liu C; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China., Liu J; Department of Neurology, Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China., Chan P; Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, China., Liu Z; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China. liuzhenhua@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. liuzhenhua@csu.edu.cn., Tang B; Department of Neurology, Multi-Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China. bstang7398@163.com.; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China. bstang7398@163.com.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. bstang7398@163.com.
Corporate Authors: Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), China Essential Tremor Alliance (CETA)
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 Mar 28; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The genetic spectrum of LRRK2 variants in Parkinson's disease: findings from a large Chinese cohort.
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            NameFull: Liu H
      – PersonEntity:
          Name:
            NameFull: Zheng H
      – PersonEntity:
          Name:
            NameFull: Chen C
      – PersonEntity:
          Name:
            NameFull: Guo H
      – PersonEntity:
          Name:
            NameFull: Xia K
      – PersonEntity:
          Name:
            NameFull: Zhang Z
      – PersonEntity:
          Name:
            NameFull: Yuan K
      – PersonEntity:
          Name:
            NameFull: Li J
      – PersonEntity:
          Name:
            NameFull: Wang J
      – PersonEntity:
          Name:
            NameFull: Guo J
      – PersonEntity:
          Name:
            NameFull: Shen L
      – PersonEntity:
          Name:
            NameFull: Jiang H
      – PersonEntity:
          Name:
            NameFull: Liu C
      – PersonEntity:
          Name:
            NameFull: Liu J
      – PersonEntity:
          Name:
            NameFull: Chan P
      – PersonEntity:
          Name:
            NameFull: Liu Z
      – PersonEntity:
          Name:
            NameFull: Tang B
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 28
              M: 03
              Text: 2026 Mar 28
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 2373-8057
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: NPJ Parkinson's disease
              Type: main
ResultId 1