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Brain structural abnormalities in treatment-resistant schizophrenia.

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Title: Brain structural abnormalities in treatment-resistant schizophrenia.
Authors: Etyemez S; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sivananthan R; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Faria AV; Departments of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Iasevoli F; Section of Psychiatry, Department of Neuroscience, University 'Federico II', Naples, Italy., Pontillo G; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.; Department of Electrical Engineering and Information Technology (DIETI), University 'Federico II', Naples, Italy., Di Giorgio A; ASST Papa Giovanni XXIII, Department of Mental Health and Addictions, Bergamo, Italy., Chung YC; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea., Kim WS; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea., Odkhuu S; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea., Kwon JS; Department of Psychiatry, Hanyang University Hospital, Seoul, South Korea.; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea., Kim M; Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea., Ha M; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea., Georgiadis F; Department of Adult Psychiatry and Psychotherapy Psychiatric University Clinic Zurich and University of Zurich, Zurich, Switzerland., Milano BA; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Kirschner M; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Kaiser S; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland., Tordesillas-Gutiérrez D; Instituto de Física de Cantabria UC-CSIC, Santander, Spain.; Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain., Sim K; West Region, Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Tan Y; Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China., Chan SKW; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China., Turner JA; Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, Columbus, OH, USA., van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, 309 Qureshey Research Lab, Irvine, CA, USA., Lee J; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; North Region, Institute of Mental Health, Singapore, Singapore., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA., Sawa A; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. asawa1@jhmi.edu., Yang K; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. kunyang@jhmi.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Aug; Vol. 31 (8), pp. 4463-4474. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Etyemez+S%22">Etyemez S</searchLink>; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sivananthan+R%22">Sivananthan R</searchLink>; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Faria+AV%22">Faria AV</searchLink>; Departments of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Iasevoli+F%22">Iasevoli F</searchLink>; Section of Psychiatry, Department of Neuroscience, University 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Pontillo+G%22">Pontillo G</searchLink>; Department of Advanced Biomedical Sciences, University 'Federico II', Naples, Italy.; Department of Electrical Engineering and Information Technology (DIETI), University 'Federico II', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giorgio+A%22">Di Giorgio A</searchLink>; ASST Papa Giovanni XXIII, Department of Mental Health and Addictions, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Chung+YC%22">Chung YC</searchLink>; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.<br /><searchLink fieldCode="AU" term="%22Kim+WS%22">Kim WS</searchLink>; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.<br /><searchLink fieldCode="AU" term="%22Odkhuu+S%22">Odkhuu S</searchLink>; Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea.; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+JS%22">Kwon JS</searchLink>; Department of Psychiatry, Hanyang University Hospital, Seoul, South Korea.; Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Ha+M%22">Ha M</searchLink>; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Georgiadis+F%22">Georgiadis F</searchLink>; Department of Adult Psychiatry and Psychotherapy Psychiatric University Clinic Zurich and University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Milano+BA%22">Milano BA</searchLink>; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kirschner+M%22">Kirschner M</searchLink>; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kaiser+S%22">Kaiser S</searchLink>; Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tordesillas-Gutiérrez+D%22">Tordesillas-Gutiérrez D</searchLink>; Instituto de Física de Cantabria UC-CSIC, Santander, Spain.; Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Sim+K%22">Sim K</searchLink>; West Region, Institute of Mental Health, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chan+SKW%22">Chan SKW</searchLink>; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Turner+JA%22">Turner JA</searchLink>; Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22van+Erp+TGM%22">van Erp TGM</searchLink>; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, 309 Qureshey Research Lab, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; North Region, Institute of Mental Health, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Calhoun+VD%22">Calhoun VD</searchLink>; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sawa+A%22">Sawa A</searchLink>; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. asawa1@jhmi.edu.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. asawa1@jhmi.edu.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. kunyang@jhmi.edu.
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