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CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions.

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Title: CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions.
Authors: Cohen-Solal JF; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA. joel.cohensolal@abbvie.com., Pohl CS; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA. calvin.pohl@abbvie.com., Cummings SM; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Gygi JP; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Safikhani Z; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Bartocha B; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Buckley CD; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK.; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Dong Y; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Eyerich K; Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany.; Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Karsen SD; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Lynch GR; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Macoritto M; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Morisset PA; AbbVie Inc., North Chicago, IL, USA., Nelson OD; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Radstake T; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Rieder F; Department of Inflammation and Immunity, Cleveland Clinic Research, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Rivas J; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Savaryn JP; AbbVie Inc., North Chicago, IL, USA., Smith KM; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Stulir M; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Szynal C; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Tylek C; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Veldman GM; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Wasserman LG; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Westmoreland S; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Chaudhary N; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA., Staron MM; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2026 Mar 28; Vol. 32 (1). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions.
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  Data: <searchLink fieldCode="AU" term="%22Cohen-Solal+JF%22">Cohen-Solal JF</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA. joel.cohensolal@abbvie.com.<br /><searchLink fieldCode="AU" term="%22Pohl+CS%22">Pohl CS</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA. calvin.pohl@abbvie.com.<br /><searchLink fieldCode="AU" term="%22Cummings+SM%22">Cummings SM</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Gygi+JP%22">Gygi JP</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Safikhani+Z%22">Safikhani Z</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Bartocha+B%22">Bartocha B</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Buckley+CD%22">Buckley CD</searchLink>; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK.; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Eyerich+K%22">Eyerich K</searchLink>; Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany.; Division of Dermatology and Venereology, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Karsen+SD%22">Karsen SD</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+GR%22">Lynch GR</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Macoritto+M%22">Macoritto M</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Morisset+PA%22">Morisset PA</searchLink>; AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+OD%22">Nelson OD</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Radstake+T%22">Radstake T</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Rieder+F%22">Rieder F</searchLink>; Department of Inflammation and Immunity, Cleveland Clinic Research, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Rivas+J%22">Rivas J</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Savaryn+JP%22">Savaryn JP</searchLink>; AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Smith+KM%22">Smith KM</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Stulir+M%22">Stulir M</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Szynal+C%22">Szynal C</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Tylek+C%22">Tylek C</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Veldman+GM%22">Veldman GM</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Wasserman+LG%22">Wasserman LG</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Westmoreland+S%22">Westmoreland S</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhary+N%22">Chaudhary N</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.<br /><searchLink fieldCode="AU" term="%22Staron+MM%22">Staron MM</searchLink>; AbbVie Inc. Bioresearch Center, 100 Research Drive, Worcester, MA, 01605, USA.
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  Data: <searchLink fieldCode="JN" term="%229501023%22">Molecular medicine (Cambridge, Mass.)</searchLink> [Mol Med] 2026 Mar 28; Vol. 32 (1). <i>Date of Electronic Publication: </i>2026 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9501023 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-3658 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210761551%22">10761551 </searchLink><i>NLM ISO Abbreviation: </i>Mol Med <i>Subsets: </i>MEDLINE
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