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Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells.

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Title: Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells.
Authors: Aoki T; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. aokitakahiro@chiba-u.jp.; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan. aokitakahiro@chiba-u.jp., Kobayashi M; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan., Okoshi M; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Yamaguchi M; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Okura H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Sasaki S; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Sasako Y; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Kira S; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Chang YH; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Yakushiji-Kaminatsui N; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Sharif J; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Matsuda M; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan., Kiuchi M; Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan., Hirahara K; Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan., Kimura MY; Department of Experimental Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan., Motohashi S; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan., Koseki H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. haruhiko.koseki@riken.jp.; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan. haruhiko.koseki@riken.jp.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 29; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells.
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  Data: <searchLink fieldCode="AU" term="%22Aoki+T%22">Aoki T</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. aokitakahiro@chiba-u.jp.; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan. aokitakahiro@chiba-u.jp.<br /><searchLink fieldCode="AU" term="%22Kobayashi+M%22">Kobayashi M</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Okoshi+M%22">Okoshi M</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+M%22">Yamaguchi M</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Okura+H%22">Okura H</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Sasaki+S%22">Sasaki S</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Sasako+Y%22">Sasako Y</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Kira+S%22">Kira S</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Chang+YH%22">Chang YH</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Yakushiji-Kaminatsui+N%22">Yakushiji-Kaminatsui N</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Sharif+J%22">Sharif J</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+M%22">Matsuda M</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.<br /><searchLink fieldCode="AU" term="%22Kiuchi+M%22">Kiuchi M</searchLink>; Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Hirahara+K%22">Hirahara K</searchLink>; Department of Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Kimura+MY%22">Kimura MY</searchLink>; Department of Experimental Immunology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Motohashi+S%22">Motohashi S</searchLink>; Department of Medical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8670, Japan.<br /><searchLink fieldCode="AU" term="%22Koseki+H%22">Koseki H</searchLink>; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. haruhiko.koseki@riken.jp.; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, 260-8670, Japan. haruhiko.koseki@riken.jp.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 Mar 29; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13287-026-04994-7
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      – TitleFull: Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells.
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