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Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.

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Title: Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.
Authors: Wang X; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA., Sofer T; Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA., Frei O; Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway; NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Perreira KM; Department of Public Policy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA., Parada H Jr; Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA 92182, USA., Zhou L; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Andreassen OA; Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway; NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway., Gonzalez H; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA., Dale AM; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA., Broce IJ; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: ibroce@health.ucsd.edu.
Source: HGG advances [HGG Adv] 2026 Jul 09; Vol. 7 (3), pp. 100597. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Sofer+T%22">Sofer T</searchLink>; Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Frei+O%22">Frei O</searchLink>; Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway; NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kaplan+R%22">Kaplan R</searchLink>; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Perreira+KM%22">Perreira KM</searchLink>; Department of Public Policy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Franceschini+N%22">Franceschini N</searchLink>; Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Parada+H+Jr%22">Parada H Jr</searchLink>; Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA 92182, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway; NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Gonzalez+H%22">Gonzalez H</searchLink>; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Dale+AM%22">Dale AM</searchLink>; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Broce+IJ%22">Broce IJ</searchLink>; Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: ibroce@health.ucsd.edu.
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              Text: 2026 Jul 09
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