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PTC-Assisted Chemoselective S-Alkylation of 5-Mercapto-1,3,4-Oxadiazol Derivative: Multi-Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis Induction.

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Title: PTC-Assisted Chemoselective S-Alkylation of 5-Mercapto-1,3,4-Oxadiazol Derivative: Multi-Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis Induction.
Authors: Zakaria A; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, Iraq.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt., Hawas SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt., Ali AK; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt., Elsayed GA; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt., Khatib AOA; Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan., Abbass EM; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Source: Drug development research [Drug Dev Res] 2026 Apr; Vol. 87 (2), pp. e70268.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE
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  Data: PTC-Assisted Chemoselective S-Alkylation of 5-Mercapto-1,3,4-Oxadiazol Derivative: Multi-Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis Induction.
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  Data: <searchLink fieldCode="AU" term="%22Zakaria+A%22">Zakaria A</searchLink>; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Al-Karmalawy+AA%22">Al-Karmalawy AA</searchLink>; Department of Pharmaceutical Chemistry, College of Pharmacy, The University of Mashreq, Baghdad, Iraq.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Hawas+SS%22">Hawas SS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.<br /><searchLink fieldCode="AU" term="%22Ali+AK%22">Ali AK</searchLink>; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elsayed+GA%22">Elsayed GA</searchLink>; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Khatib+AOA%22">Khatib AOA</searchLink>; Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.<br /><searchLink fieldCode="AU" term="%22Abbass+EM%22">Abbass EM</searchLink>; Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
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      – TitleFull: PTC-Assisted Chemoselective S-Alkylation of 5-Mercapto-1,3,4-Oxadiazol Derivative: Multi-Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis Induction.
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              Text: 2026 Apr
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