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Betulin inhibits titanium particle-induced osteolysis and attenuates RANKL-associated osteoclastogenesis by suppressing the MAPK pathway.

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Title: Betulin inhibits titanium particle-induced osteolysis and attenuates RANKL-associated osteoclastogenesis by suppressing the MAPK pathway.
Authors: Shen TS; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC; Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan, ROC., Huang YF; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC., Hsu CS; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC., Hsieh CP; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, No. 250, Kuo-Kuang Rd., Taichung, 40227, Taiwan, ROC; Department of Kinesiology, Health and Leisure Studies, Chien Kuo Technology University, No.1, Chieh-Shou N. Rd., Changhua, 50094, Taiwan, ROC., Chen HY; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC. Electronic address: 180342@cch.org.tw., Chou MC; Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan, ROC; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan, ROC. Electronic address: mcchou@csmu.edu.tw.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Apr 15; Vol. 1021, pp. 178828. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Betulin inhibits titanium particle-induced osteolysis and attenuates RANKL-associated osteoclastogenesis by suppressing the MAPK pathway.
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  Data: <searchLink fieldCode="AU" term="%22Shen+TS%22">Shen TS</searchLink>; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC; Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Huang+YF%22">Huang YF</searchLink>; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsu+CS%22">Hsu CS</searchLink>; Frontier Molecular Medical Research Center in Children, Changhua Christian Children Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsieh+CP%22">Hsieh CP</searchLink>; Department of Orthopedic Surgery, Changhua Christian Hospital, Changhua, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, No. 250, Kuo-Kuang Rd., Taichung, 40227, Taiwan, ROC; Department of Kinesiology, Health and Leisure Studies, Chien Kuo Technology University, No.1, Chieh-Shou N. Rd., Changhua, 50094, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chen+HY%22">Chen HY</searchLink>; Orthopedics & Sports Medicine Laboratory, Changhua Christian Hospital, No. 235 Shi-Guan Rd., Changhua, 50006, Taiwan, ROC. Electronic address: 180342@cch.org.tw.<br /><searchLink fieldCode="AU" term="%22Chou+MC%22">Chou MC</searchLink>; Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan, ROC; Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan, ROC. Electronic address: mcchou@csmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2026 Apr 15; Vol. 1021, pp. 178828. <i>Date of Electronic Publication: </i>2026 Mar 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1254354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0712 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200142999%22">00142999 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejphar.2026.178828
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              Text: 2026 Apr 15
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