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The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.

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Title: The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.
Authors: Choi RB; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Yoon SH; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Kotsalidis PE; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Houghton CH; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., George M; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Brooks DJ; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Zhao Y; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Bouxsein ML; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States., Wein MN; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States.; Harvard Stem Cell Institute, Cambridge, MA 02138, United States.
Source: JBMR plus [JBMR Plus] 2026 Mar 06; Vol. 10 (4), pp. ziag032. Date of Electronic Publication: 2026 Mar 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101707013 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-4039 (Electronic) Linking ISSN: 24734039 NLM ISO Abbreviation: JBMR Plus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.
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  Data: <searchLink fieldCode="AU" term="%22Choi+RB%22">Choi RB</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Yoon+SH%22">Yoon SH</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Kotsalidis+PE%22">Kotsalidis PE</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Houghton+CH%22">Houghton CH</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22George+M%22">George M</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Brooks+DJ%22">Brooks DJ</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Bouxsein+ML%22">Bouxsein ML</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.<br /><searchLink fieldCode="AU" term="%22Wein+MN%22">Wein MN</searchLink>; Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, United States.; Harvard Stem Cell Institute, Cambridge, MA 02138, United States.
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  Data: <searchLink fieldCode="JN" term="%22101707013%22">JBMR plus</searchLink> [JBMR Plus] 2026 Mar 06; Vol. 10 (4), pp. ziag032. <i>Date of Electronic Publication: </i>2026 Mar 06 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101707013 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2473-4039 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224734039%22">24734039 </searchLink><i>NLM ISO Abbreviation: </i>JBMR Plus <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1093/jbmrpl/ziag032
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        Text: English
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      – TitleFull: The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.
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            – D: 06
              M: 03
              Text: 2026 Mar 06
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              Y: 2026
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