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Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4.

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Title: Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4.
Authors: Naqvi AS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Sullivan PJ; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States., Corbett RJ; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States., Sehgal P; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Conkrite KL; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Rathi KS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Ennis BM; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Hayer KE; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Zhang B; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Brown MA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Miller DP; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Sickler A; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States., Kraya AA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Coleman KL; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States., Dybas JM; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Geng Z; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Blackden C; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Arif S; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Chroni A; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Lahiri A; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Hollawell ML; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Storm PB; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Haydar D; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States., Foster JB; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States., Koptyra M; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Madsen PJ; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Diskin SJ; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States., Thomas-Tikhonenko A; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States., Resnick AC; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States., Rokita JL; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Source: Neuro-oncology pediatrics [Neurooncol Pediatr] 2026 Feb 16; Vol. 2 (1), pp. wuag009. Date of Electronic Publication: 2026 Feb 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology Country of Publication: England NLM ID: 9919209371606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2977-4454 (Electronic) Linking ISSN: 29774454 NLM ISO Abbreviation: Neurooncol Pediatr Subsets: PubMed not MEDLINE
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  Data: Alternative splicing in pediatric central nervous system tumors highlights oncofetal candidate CLK1 exon 4.
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  Data: <searchLink fieldCode="AU" term="%22Naqvi+AS%22">Naqvi AS</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Sullivan+PJ%22">Sullivan PJ</searchLink>; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Corbett+RJ%22">Corbett RJ</searchLink>; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Sehgal+P%22">Sehgal P</searchLink>; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Conkrite+KL%22">Conkrite KL</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Rathi+KS%22">Rathi KS</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Ennis+BM%22">Ennis BM</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Hayer+KE%22">Hayer KE</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Brown+MA%22">Brown MA</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Miller+DP%22">Miller DP</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Sickler+A%22">Sickler A</searchLink>; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Kraya+AA%22">Kraya AA</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Coleman+KL%22">Coleman KL</searchLink>; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Dybas+JM%22">Dybas JM</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Geng+Z%22">Geng Z</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Blackden+C%22">Blackden C</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Arif+S%22">Arif S</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Chroni+A%22">Chroni A</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Lahiri+A%22">Lahiri A</searchLink>; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Hollawell+ML%22">Hollawell ML</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Storm+PB%22">Storm PB</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Haydar+D%22">Haydar D</searchLink>; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.<br /><searchLink fieldCode="AU" term="%22Foster+JB%22">Foster JB</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Koptyra+M%22">Koptyra M</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Madsen+PJ%22">Madsen PJ</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Diskin+SJ%22">Diskin SJ</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Thomas-Tikhonenko+A%22">Thomas-Tikhonenko A</searchLink>; Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, United States.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Resnick+AC%22">Resnick AC</searchLink>; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Rokita+JL%22">Rokita JL</searchLink>; Center for Cancer and Immunology Research, Children's National Hospital, Washington, DC, United States.; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
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  Data: <searchLink fieldCode="JN" term="%229919209371606676%22">Neuro-oncology pediatrics</searchLink> [Neurooncol Pediatr] 2026 Feb 16; Vol. 2 (1), pp. wuag009. <i>Date of Electronic Publication: </i>2026 Feb 16 (<i>Print Publication: </i>2026).
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