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Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6.

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Title: Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6.
Authors: Li Y; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Wang Y; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Feng X; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Zhang L; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Wang Q; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Liu X; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Ma T; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Zhang P; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Du Y; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Qin M; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China., Ma J; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 Mar 23; Vol. 20, pp. 574294. Date of Electronic Publication: 2026 Mar 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Feng+X%22">Feng X</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+T%22">Ma T</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Du+Y%22">Du Y</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Qin+M%22">Qin M</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Orthopaedic Institute of Integrated Traditional Chinese and Western Medicine, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Tianjin Hospital, Tianjin University, Tianjin, 301617, People's Republic of China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin, 300050, People's Republic of China.
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        Value: 10.2147/DDDT.S574294
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        Text: English
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      – TitleFull: Computational and Experimental Biology Reveals Dihydroartemisinin's Efficacy Against Steroid-Induced Osteonecrosis of the Femoral Head Adjusting Ferroptosis via CCL17-PRDX6.
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              Text: 2026 Mar 23
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