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VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia.

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Title: VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia.
Authors: Yamaguchi A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Putzbach V; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Adili R; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Lazar S; Center for Hemostasis, Thrombosis and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA., Stanger L; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Gilmore D; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Maloney DJ; Veralox Therapeutics, Frederick, MD., McKenzie SE; Center for Hemostasis, Thrombosis and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA., Michael JV; Center for Hemostasis, Thrombosis and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA., Holinstat M; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
Source: Blood vessels, thrombosis & hemostasis [Blood Vessel Thromb Hemost] 2026 Mar 03; Vol. 3 (2), pp. 100146. Date of Electronic Publication: 2026 Mar 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918957761606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2950-3272 (Electronic) Linking ISSN: 29503272 NLM ISO Abbreviation: Blood Vessel Thromb Hemost Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia.
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  Data: <searchLink fieldCode="AU" term="%22Yamaguchi+A%22">Yamaguchi A</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Putzbach+V%22">Putzbach V</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Adili+R%22">Adili R</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Lazar+S%22">Lazar S</searchLink>; Center for Hemostasis, Thrombosis and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Stanger+L%22">Stanger L</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Gilmore+D%22">Gilmore D</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Maloney+DJ%22">Maloney DJ</searchLink>; Veralox Therapeutics, Frederick, MD.<br /><searchLink fieldCode="AU" term="%22McKenzie+SE%22">McKenzie SE</searchLink>; Center for Hemostasis, Thrombosis and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Michael+JV%22">Michael JV</searchLink>; Center for Hemostasis, Thrombosis and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Holinstat+M%22">Holinstat M</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI.
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  Data: <searchLink fieldCode="JN" term="%229918957761606676%22">Blood vessels, thrombosis & hemostasis</searchLink> [Blood Vessel Thromb Hemost] 2026 Mar 03; Vol. 3 (2), pp. 100146. <i>Date of Electronic Publication: </i>2026 Mar 03 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918957761606676 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2950-3272 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2229503272%22">29503272 </searchLink><i>NLM ISO Abbreviation: </i>Blood Vessel Thromb Hemost <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.bvth.2026.100146
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        Text: English
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              Text: 2026 Mar 03
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