Transdermal bicarbonate buffer therapy increases intratumoral pH and elicits antitumor responses in bladder cancer.

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Title: Transdermal bicarbonate buffer therapy increases intratumoral pH and elicits antitumor responses in bladder cancer.
Authors: Oluwatola O; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; Department of Molecular Medicine, University of South Florida, Tampa, FL, United States., Bazargan S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; College of Arts and Sciences, University of South Florida, Tampa, FL, United States., Irrera P; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Chang D; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Thomas A; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Blauvelt J; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Beatty M; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Hall M; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Whelan CJ; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; Department of Biological Sciences, University of Illinois, Chicago, IL, United States., Estrella V; Department of Molecular Medicine, University of South Florida, Tampa, FL, United States., Rejniak KA; Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Poch M; Genitourinary Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States., Fitzsimmons N; Dyve Biosciences, Inc., Camarillo, CA, United States., Beal R; Dyve Biosciences, Inc., Camarillo, CA, United States., Ibrahim-Hashim A; Faculty of Education and Arts, Sohar University, Sohar, Oman., Pilon-Thomas S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; Genitourinary Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 13; Vol. 17, pp. 1706250. Date of Electronic Publication: 2026 Mar 13 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Transdermal bicarbonate buffer therapy increases intratumoral pH and elicits antitumor responses in bladder cancer.
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  Data: <searchLink fieldCode="AU" term="%22Oluwatola+O%22">Oluwatola O</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; Department of Molecular Medicine, University of South Florida, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Bazargan+S%22">Bazargan S</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; College of Arts and Sciences, University of South Florida, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Irrera+P%22">Irrera P</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Chang+D%22">Chang D</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Thomas+A%22">Thomas A</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Blauvelt+J%22">Blauvelt J</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Beatty+M%22">Beatty M</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Hall+M%22">Hall M</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Whelan+CJ%22">Whelan CJ</searchLink>; Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; Department of Biological Sciences, University of Illinois, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Estrella+V%22">Estrella V</searchLink>; Department of Molecular Medicine, University of South Florida, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Rejniak+KA%22">Rejniak KA</searchLink>; Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Poch+M%22">Poch M</searchLink>; Genitourinary Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.<br /><searchLink fieldCode="AU" term="%22Fitzsimmons+N%22">Fitzsimmons N</searchLink>; Dyve Biosciences, Inc., Camarillo, CA, United States.<br /><searchLink fieldCode="AU" term="%22Beal+R%22">Beal R</searchLink>; Dyve Biosciences, Inc., Camarillo, CA, United States.<br /><searchLink fieldCode="AU" term="%22Ibrahim-Hashim+A%22">Ibrahim-Hashim A</searchLink>; Faculty of Education and Arts, Sohar University, Sohar, Oman.<br /><searchLink fieldCode="AU" term="%22Pilon-Thomas+S%22">Pilon-Thomas S</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.; Genitourinary Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States.
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