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Excess and Dysfunctional Fat as a Primary Driver of Heart Failure With Preserved Ejection Fraction: From Institutional Recognition to Clinical Integration.

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Title: Excess and Dysfunctional Fat as a Primary Driver of Heart Failure With Preserved Ejection Fraction: From Institutional Recognition to Clinical Integration.
Authors: Packer M; Baylor Heart and Vascular Institute, Dallas, Texas, USA; Imperial College, London, United Kingdom. Electronic address: milton.packer@baylorhealth.edu., Ho J; Harvard Medical School, Boston, Massachusetts, USA; CardioVascular Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Petrie MC; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom., Schiattarella GG; Max Rubner Center for Cardiovascular Metabolic Renal Research, Deutsches Herzzentrum der Charité, Charité-Universitätsmedizin, German Centre for Cardiovascular Research, Partner Site Berlin, Berlin, Germany; Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy., Butler J; Baylor Scott and White Research Institute, Dallas, Texas, USA; University of Mississippi School of Medicine, Jackson, Mississippi, USA., Lam CSP; Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore Medical School, Singapore, Singapore; National Heart Centre Singapore, Singapore., Vaduganathan M; Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Zannad F; Centres d'Investigation Clinique, INSERM, Centre Hospitalier Régional Universitaire de Nancy, Université de Lorraine, Nancy, France., Borlaug BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Source: JACC. Heart failure [JACC Heart Fail] 2026 Jun; Vol. 14 (6), pp. 103046. Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101598241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1787 (Electronic) Linking ISSN: 22131779 NLM ISO Abbreviation: JACC Heart Fail Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Excess and Dysfunctional Fat as a Primary Driver of Heart Failure With Preserved Ejection Fraction: From Institutional Recognition to Clinical Integration.
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  Data: <searchLink fieldCode="AU" term="%22Packer+M%22">Packer M</searchLink>; Baylor Heart and Vascular Institute, Dallas, Texas, USA; Imperial College, London, United Kingdom. Electronic address: milton.packer@baylorhealth.edu.<br /><searchLink fieldCode="AU" term="%22Ho+J%22">Ho J</searchLink>; Harvard Medical School, Boston, Massachusetts, USA; CardioVascular Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Petrie+MC%22">Petrie MC</searchLink>; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schiattarella+GG%22">Schiattarella GG</searchLink>; Max Rubner Center for Cardiovascular Metabolic Renal Research, Deutsches Herzzentrum der Charité, Charité-Universitätsmedizin, German Centre for Cardiovascular Research, Partner Site Berlin, Berlin, Germany; Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Butler+J%22">Butler J</searchLink>; Baylor Scott and White Research Institute, Dallas, Texas, USA; University of Mississippi School of Medicine, Jackson, Mississippi, USA.<br /><searchLink fieldCode="AU" term="%22Lam+CSP%22">Lam CSP</searchLink>; Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore Medical School, Singapore, Singapore; National Heart Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Vaduganathan+M%22">Vaduganathan M</searchLink>; Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zannad+F%22">Zannad F</searchLink>; Centres d'Investigation Clinique, INSERM, Centre Hospitalier Régional Universitaire de Nancy, Université de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Borlaug+BA%22">Borlaug BA</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
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  Data: <searchLink fieldCode="JN" term="%22101598241%22">JACC. Heart failure</searchLink> [JACC Heart Fail] 2026 Jun; Vol. 14 (6), pp. 103046. <i>Date of Electronic Publication: </i>2026 Mar 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101598241 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-1787 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222131779%22">22131779 </searchLink><i>NLM ISO Abbreviation: </i>JACC Heart Fail <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jchf.2026.103046
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      – Code: eng
        Text: English
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        StartPage: 103046
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              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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