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PRDM16 protects retinal ganglion cells from ischemia-reperfusion Injury by regulating the RPL5/p53 axis.

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Title: PRDM16 protects retinal ganglion cells from ischemia-reperfusion Injury by regulating the RPL5/p53 axis.
Authors: Feng Y; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., Li Z; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., Lu J; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., Peng X; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., He Z; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., Jia A; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., Bao Y; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China., Zheng Q; Department of Emergency, Sichuan, China.; Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China., Xu X; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China., Ma Y; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China., Zou C; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China., Li H; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China. lihuiling@csu.edu.cn.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China. lihuiling@csu.edu.cn., Zhang D; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China. dongshanzhang@csu.edu.cn.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. dongshanzhang@csu.edu.cn.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China. dongshanzhang@csu.edu.cn.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 30; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
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  Data: PRDM16 protects retinal ganglion cells from ischemia-reperfusion Injury by regulating the RPL5/p53 axis.
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  Data: <searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Jia+A%22">Jia A</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Bao+Y%22">Bao Y</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zheng+Q%22">Zheng Q</searchLink>; Department of Emergency, Sichuan, China.; Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zou+C%22">Zou C</searchLink>; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, China. lihuiling@csu.edu.cn.; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan, China. lihuiling@csu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Renming Middle Road, Changsha, Hunan, 410011, People's Republic of China. dongshanzhang@csu.edu.cn.; Emergency Medicine and Difficult Diseases Institute, Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. dongshanzhang@csu.edu.cn.; Furong Laboratory, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China. dongshanzhang@csu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Mar 30; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Mar 30.
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        Value: 10.1007/s00018-026-06187-0
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        Text: English
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      – TitleFull: PRDM16 protects retinal ganglion cells from ischemia-reperfusion Injury by regulating the RPL5/p53 axis.
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