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Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans.

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Title: Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans.
Authors: García-Domínguez E; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain., García-Domínguez C; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Department of Internal Medicine, Hospital Universitario Royo Villanova, Zaragoza 50015, Spain., Cabrera-Alarcón JL; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain., Muñoz-Hernández MDM; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain., Hernansanz-Agustín P; Centro de Neurociencias Cajal, Alcalá de Henares 28805, Spain., Curtabbi A; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain., Domenech-Fernandez J; Servicio de Cirugía Ortopédica y Traumatología, Hospital Arnau de Vilanova y Hospital de Liria and Health Care Department Arnau-Lliria, Valencia 46015, Spain.; Department of Orthopedic Surgery, Clinica Universidad de Navarra, Pamplona 31008, Spain., Calvo E; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares Instituto de Salud Carlos III, Madrid 28029, Spain., Vázquez J; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares Instituto de Salud Carlos III, Madrid 28029, Spain., Serrano AL; Altos Labs, San Diego Institute of Science, San Diego, CA 92121., Muñoz-Cánoves P; Altos Labs, San Diego Institute of Science, San Diego, CA 92121., Olaso-González G; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain., Enríquez JA; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain.; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain., Gómez-Cabrera MC; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 07; Vol. 123 (14), pp. e2508286123. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans.
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  Data: <searchLink fieldCode="AU" term="%22García-Domínguez+E%22">García-Domínguez E</searchLink>; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22García-Domínguez+C%22">García-Domínguez C</searchLink>; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Department of Internal Medicine, Hospital Universitario Royo Villanova, Zaragoza 50015, Spain.<br /><searchLink fieldCode="AU" term="%22Cabrera-Alarcón+JL%22">Cabrera-Alarcón JL</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz-Hernández+MDM%22">Muñoz-Hernández MDM</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Hernansanz-Agustín+P%22">Hernansanz-Agustín P</searchLink>; Centro de Neurociencias Cajal, Alcalá de Henares 28805, Spain.<br /><searchLink fieldCode="AU" term="%22Curtabbi+A%22">Curtabbi A</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Domenech-Fernandez+J%22">Domenech-Fernandez J</searchLink>; Servicio de Cirugía Ortopédica y Traumatología, Hospital Arnau de Vilanova y Hospital de Liria and Health Care Department Arnau-Lliria, Valencia 46015, Spain.; Department of Orthopedic Surgery, Clinica Universidad de Navarra, Pamplona 31008, Spain.<br /><searchLink fieldCode="AU" term="%22Calvo+E%22">Calvo E</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares Instituto de Salud Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Vázquez+J%22">Vázquez J</searchLink>; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares Instituto de Salud Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Serrano+AL%22">Serrano AL</searchLink>; Altos Labs, San Diego Institute of Science, San Diego, CA 92121.<br /><searchLink fieldCode="AU" term="%22Muñoz-Cánoves+P%22">Muñoz-Cánoves P</searchLink>; Altos Labs, San Diego Institute of Science, San Diego, CA 92121.<br /><searchLink fieldCode="AU" term="%22Olaso-González+G%22">Olaso-González G</searchLink>; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Enríquez+JA%22">Enríquez JA</searchLink>; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain.; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Cabrera+MC%22">Gómez-Cabrera MC</searchLink>; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Fundación Investigación Hospital Clínico Universitario/Incliva Fundación Investigación Hospital Clínico Universitario, Valencia 46010, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable Instituto de Salud Carlos III, Madrid 28029, Spain.
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